Utility of some Heamatological Parameters in Diagnosis of recent onset Type One Diabetes :a case control study | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 12 May 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2025.376832.1937 | ||
| Authors | ||
| Noura Mohammed ElBakry* 1; Ahlam Mohamed Ismail2; naglaa makram farag3; Maisa mohamed alanwar abdelhameed4 | ||
| 1Pediatric Department, Faculty of Medicine, Minya University, Egypt | ||
| 2Pediatrics, Midicine,Minia University | ||
| 3alminya | ||
| 4Resident at pediatric and neonatology department, faculty of Medicine, Minia University, Egypt | ||
| Abstract | ||
| Type one Diabetes (T1D) is an autoimmune disease and is usually due to impairment the immune system including monocytes. This article provides an in-depth analysis of select hematological parameters, including white blood cells, lymphocytes, monocytes, and the monocyte-to-lymphocyte ratio, highlighting their significance in the pathogenesis of T1D. The white blood cell (WBC) count, its subtypes, and the monocyte-to-lymphocyte ratio (MLR) are recognized markers of inflammation in diverse pathological conditions. Monocyte subsets, defined by CD14 and CD16 expression, play distinct roles in inflammation. The CD14+CD16+ subset, in particular, is pro-inflammatory. Researching the impact of these subsets on T1D in young children could reveal new avenues for understanding disease pathogenesis and prognosis. Objective: To analyzing the relationship between hematological parameters and type 1 diabetes, with a focus on pathophysiology. Methods: a case control study including forty children (Group I)with recent onset type one diabetes, their age between 5 to15 years old, and Group II (control group) consisted of 25 children. Peripheral blood mononuclear cell was incubated for 24 hours and levels of CD14+ & CD16+ were measured, and monocyte-to-lymphocyte ratio was calculated using the equation (LMR= absolute lymphocyte count / absolute monocyte count). Results: We found a significant difference in the presence of intermediate monocytes CD14+, CD16+ in diabetic group compared to control group. Fasting blood glucose levels were directly associated with the frequency of CD14+CD16+ monocytes. Conclusion: According to the significant diversities of hematological parameters and monocyte subtypes between patients group, these markers could be used as diagnostic markers for T1DM. | ||
| Keywords | ||
| type 1 diabetes; monocytes; lymphocytes | ||
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