Protective Effect of Matcha Tea Against Hepato-Renal Injury Induced by Chloroquine in Mice | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 01 December 2025 PDF (1.19 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.375243.2785 | ||
| Authors | ||
| Asmaa M. Shoieb1; Eman E. Abd Elhady1; Yosra H. Darwish1; Mohamed Elzallat* 2 | ||
| 1Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Egypt. | ||
| 2Immunology Department, Theodor Bilharz Research Institute | ||
| Abstract | ||
| Chloroquine (CQ) is a widely used 4-aminoquinoline drug that can cause damage to the liver and kidney. Matcha green tea (MGT) is known for its positive effects on human health, offering a range of biological benefits, including chemopreventive, mood-boosting, antioxidant properties. This study aimed to evaluate the protective effects of MGT against hepatotoxicity and renal injury induced by CQ in mice. Forty-two male Swiss albino mice weighing 20-25g were divided randomly into six groups. Group 1 (7 mice, negative control) was fed a basal diet. Mice in groups 2-6 were given a basal diet + received an oral dose (360 mg/kg B.wt.) of CQ on day 25th of the experiment. Group 2 (7 mice) kept as positive control. 3rd and 4th groups of mice received a daily dose of MGT aqueous extract (50 and 100 mg/kg B.wt. respectively). The 5th and 6th groups of mice received a daily dose of MGT infusion (50 and 100 mg/kg B.wt. respectively). The experiment lasted for 28 days. Chemical composition and polyphenol compounds in Matcha were estimated. The results indicated that the protection by Matcha resulted in decreased liver enzymes and kidney function parameters levels induced by CQ. The histopathological findings provided confirmation of these findings. This suggests that Matcha has potential prophylactic effects against hepatotoxicity and renal injury induced by CQ in mice, possibly due to its abundant active phenolic compounds. | ||
| Keywords | ||
| Hepatotoxicity; Renal Injury; Chloroquine; Matcha | ||
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