Pathological and Clinical Overview of Mucormycosis: Post-COVID-19 Perspective. | ||||
| Zagazig University Medical Journal | ||||
| Volume 31, Issue 7, July 2025, Page 2567-2575 PDF (920.23 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2025.367520.3876 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Heba Mohamed Mahmoud Hamdy  1; Mona saeed Mustafa Mohammed2
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| 1Otorhinolaryngology department faculty of medicine Zagazig University | ||||
| 2Pathology department Faculty of medicine Zagazig university | ||||
| Abstract | ||||
| Background; Mucormycosis, a severe fungal infection caused by Mucorales, has emerged as a significant post-COVID-19 complication, particularly in immunocompromised individuals. The widespread use of corticosteroids and underlying conditions such as diabetes mellitus have contributed to the increased prevalence of this opportunistic infection .This study aims to evaluate the clinical presentations, risk factors, histopathological findings, and treatment outcomes of mucormycosis in post-COVID-19 patients. Methods;A retrospective observational study was conducted over three years (2021–2023) at the Faculty of Medicine, Zagazig University. Seventy post-COVID-19 patients diagnosed with mucormycosis were included. Clinical data, imaging findings, and histopathological examination of tissue biopsy samples were analyzed. The fungal burden, presence of necrosis, angioinvasion, and perineural invasion were assessed. Results; Of the 70 patients, 70% were male, with a mean age of 41–50 years. Diabetes mellitus was the most common comorbidity (98.6%), and 90% had received corticosteroids for COVID-19 treatment. Rhino-orbital mucormycosis was the predominant form (65 cases), with severe fungal load observed in 20% of patients. Angioinvasion and perineural invasion were linked to poorer prognosis. Functional endoscopic sinus surgery was the most commonly performed intervention. Conclusion; Post-COVID-19 mucormycosis is associated with significant morbidity and mortality. Uncontrolled diabetes and corticosteroid use are major risk factors. Early diagnosis, aggressive surgical intervention, and antifungal therapy are crucial for improving patient outcomes. Keywords: Mucormycosis; COVID-19; diabetes; corticosteroids; histopathology. | ||||
| Keywords | ||||
| Mucormycosis; COVID-19; diabetes; corticosteroids; histopathology | ||||
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