The diagnostic value of lncRNA UCA1 in multiple myeloma patients in relation to miRNA-331-3p
Fikry, A., Esawy, M., Abd-elhameed, A., Waley, A., Abdullah, R. (2025). The diagnostic value of lncRNA UCA1 in multiple myeloma patients in relation to miRNA-331-3p. EKB Journal Management System, 3(3), 90-98. doi: 10.21608/ijhegy.2025.383340.1060
Abeer A. Fikry; Marwa M. Esawy; Amir Abd-elhameed; Ahmad B. Waley; Rania M Abdullah. "The diagnostic value of lncRNA UCA1 in multiple myeloma patients in relation to miRNA-331-3p". EKB Journal Management System, 3, 3, 2025, 90-98. doi: 10.21608/ijhegy.2025.383340.1060
Fikry, A., Esawy, M., Abd-elhameed, A., Waley, A., Abdullah, R. (2025). 'The diagnostic value of lncRNA UCA1 in multiple myeloma patients in relation to miRNA-331-3p', EKB Journal Management System, 3(3), pp. 90-98. doi: 10.21608/ijhegy.2025.383340.1060
Fikry, A., Esawy, M., Abd-elhameed, A., Waley, A., Abdullah, R. The diagnostic value of lncRNA UCA1 in multiple myeloma patients in relation to miRNA-331-3p. EKB Journal Management System, 2025; 3(3): 90-98. doi: 10.21608/ijhegy.2025.383340.1060

The diagnostic value of lncRNA UCA1 in multiple myeloma patients in relation to miRNA-331-3p

International Journal of Health Sciences (Egypt)
Volume 3, Issue 3, July 2025, Page 90-98  XML PDF (870.82 K)
Document Type: Original Article
DOI: 10.21608/ijhegy.2025.383340.1060
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Authors
Abeer A. Fikry1; Marwa M. Esawyorcid 1; Amir Abd-elhameed2; Ahmad B. Waley3; Rania M Abdullah email orcid 1
1Clinical Pathology Department, Faculty of Human Medicine, Zagazig University, Egypt
2Internal Medicine Department, Faculty of Human Medicine, Zagazig University, Egypt
3Medical Oncology Department, Faculty of Human Medicine, Zagazig University, Egypt
Abstract
Background: One type of malignant plasma cell disease is multiple myeloma (MM). MiR-331-3p contains the potential binding sites of LncRNA human urothelial carcinoma associated 1 (UCA1). The purpose of this study was to assess the significance of serum lncRNA UCA1 to MM diagnosis in relation to miRNA-331-3p. Methods: This study type was a case-control observational design. Serum from 53 patients with MM who were recently diagnosed and 53 age- and sex- matched healthy controls was collected. The expressions of lncRNA UCA1 and miRNA 331-3p were detected by real-time qPCR. Results: The lncRNA UCA-1 was highly expressed in MM patients, and miRNA 331-3p was down-expressed. Serum lncRNA UCA-1 levels were significantly increased with ISS stages. However, lncRNA UCA-1 expression levels did not differ with Durie-Salmon stages, renal dysfunction, and bone damage. On the other hand, miRNA 331-3p expression levels were significantly reduced with Durie-Salmon stages and bone damage. The lncRNA UCA-1 expression showed a sensitivity and specificity of 88.7% and 100%. The miRNA 331-3p expression showed a sensitivity and specificity of 83% and 100%. Multivariate analysis showed that lncRNA UCA1 (p=0.016) and miRNA 331-3p (p=0.008) were independent predictors for MM diagnosis. Conclusions: High expression of lncRNA UCA1 was detected in myeloma patients, which increased significantly with ISS. The miRNA331-3p was downregulated in MM. Both markers seem to be predictors for MM diagnosis, but the lncRNA UCA1 showed higher sensitivity and specificity. The lncRNA UCA1 and miRNA 331-3p were independent predictors for MM diagnosis.
Keywords
Keywords: Diagnostic; lncRNA UCA1; Marker; Multiple myeloma
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