Ameliorative effect of curcumin and curcumin nanoparticles against CFA-induced arthritis in adult male Wistar rats

Hamdy, Soha M.; Hamdy, Esraa A.; Mohamed, Heba R.; Sayed, Ola Nabil

doi:10.21608/ejchem.2025.365369.11388

	Ameliorative effect of curcumin and curcumin nanoparticles against CFA-induced arthritis in adult male Wistar rats
Egyptian Journal of Chemistry
Articles in Press, Accepted Manuscript, Available Online from 13 May 2025
Document Type: Original Article
DOI: 10.21608/ejchem.2025.365369.11388
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Authors
Soha M. Hamdy¹; Esraa A. Hamdy ¹; Heba R. Mohamed ²; Ola Nabil Sayed¹
¹Department of Chemistry, Biochemistry Division, Faculty of Science, El Fayoum University, El-Fayoum,
²Department of Zoology, Faculty of Science, El Fayoum University, El-Fayoum,
Abstract
This research was accomplished to clarify the effect of curcumin (Cur) and curcumin nanoparticles (Cur-NPs) on rheumatoid arthritis (RA). 48 male rats were divided randomly into groups (I): control; group (II): Cur group; group (III): Cur-NPs group; group IV: RA group; group V: Cur Treated (Tr) group; group VI: Cur-NPs Tr group; group VII: Cur Protective (Pr) group; group VIII: Cur-NPs Pr group; There was significant increase in serum MDA, RF, Anti-CCP, IL-6, and TNF- α levels and a greatly marked drop in levels of total antioxidant (TAC) in the rheumatoid arthritis (RA) group in comparison to control group with improvement their levels in groups(V- VIII). In conclusion, our result showed that the administration of Cur and Cur-Nps provided antioxidant and anti-arthritic effects against the toxicity of CFA. The histological and x-ray findings confirm the biochemical observations.
Keywords
Curcumin (Cur); Curcumin nanoparticles (Cur-Nps); Rheumatoid arthritis (RA)


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