Ameliorative Effect of Curcumin and Curcumin Nanoparticles against CFA-induced Arthritis in Adult Male Wistar Rats | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 13, December 2025, Pages 227-236 PDF (624.85 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2025.365369.11388 | ||
| Authors | ||
| Soha M. Hamdy1; Esraa A. Hamdy* 1; Heba R. Mohamed2; Ola Nabil Sayed1 | ||
| 1Department of Chemistry, Biochemistry Division, Faculty of Science, El Fayoum University, El-Fayoum, | ||
| 2Department of Zoology, Faculty of Science, El Fayoum University, El-Fayoum, | ||
| Abstract | ||
| This research was accomplished to clarify the effect of curcumin (Cur) and curcumin nanoparticles (Cur-NPs) on rheumatoid arthritis (RA). 48 male rats were divided randomly into groups (I): control; group (II): Cur group; group (III): Cur-NPs group; group IV: RA group; group V: Cur Treated (Tr) group; group VI: Cur-NPs Tr group; group VII: Cur Protective (Pr) group; group VIII: Cur-NPs Pr group; There was significant increase in serum MDA, RF, Anti-CCP, IL-6, and TNF- α levels and a greatly marked drop in levels of total antioxidant (TAC) in the rheumatoid arthritis (RA) group in comparison to control group with improvement their levels in groups(V- VIII). In conclusion, our result showed that the administration of Cur and Cur-Nps provided antioxidant and anti-arthritic effects against the toxicity of CFA. The histological and x-ray findings confirm the biochemical observations. | ||
| Keywords | ||
| Curcumin (Cur); Curcumin nanoparticles (Cur-Nps); Rheumatoid arthritis (RA) | ||
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