Comprehensive Screening of Stabilizers and Solvents for Curcumin Nanosuspension | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Articles in Press, Accepted Manuscript, Available Online from 13 May 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2025.358893.2433 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amina Mudhafar Al-Nima   1; Myasar Mohammed Alkotaji 2; Nawar Mikhael Toma3; Rasha Khalid Dhahir 1; Eman B. H. Al-khedairy 3
| ||||
| 1Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq | ||||
| 2Department of Pharmaceutics, College of Pharmacy, Nineveh University | ||||
| 3Department of Pharmaceutics, College of Pharmacy, University of Baghdad | ||||
| Abstract | ||||
| Poorly soluble drugs pose challenges in product formulation due to low solubility and bioavailability. Nanosuspensions can improve solubility and bioavailability, but optimal preparation techniques, solvent, stabilizer, and drug-to-stabilizer ratio are crucial. This work aims to optimize the preparation process of Curcumin nanosuspension. In addition, it aims in screening of the effectiveness of different stabilizers, solvents, and ratios of drug to stabilizers. Stabilizers tested included polymers (e.g., PVP30, HPMC) and surfactants (e.g., Tween 40, Poloxamer 407) in varying proportions of drug-to-stabilizer ratios were tried to choose the best stabilizer. Solvents were used as a mixture of acetone and ethanol or as a sole solvent, ethanol alone. The preparation of Curcumin (CRN) nanosuspension was accomplished by the solvent-antisolvent method using three different techniques: magnetic stirring, ultra-sonication bath, and ultra-sonication probe. Optimization of the selected formula was established by determination of particle size, polydispersity index, and zeta potential. In addition, the investigations included measurement of entrapment efficiency, CRN loading and pH. Stability test was conducted on Curcumin nanosuspension (the selected formula) over 2 months at 25˚C and 4˚C. The study found that ethanol as a solvent was superior to acetone-ethanol mixture and magnetic stirring was more effective than ultra-sonication methods, with the best nanosuspension formula being CRN-24. The main conclusion of this study is that optimal solvent, stabilizer, and drug-to-stabilizer ratio are essential for stable curcumin nanosuspensions. | ||||
| Keywords | ||||
| Curcumin; Nanosuspension; Polyvinylpyrrolidone 30; Solvent-antisolvent technique; Stabilizer | ||||
|
Statistics Article View: 152 |
||||
