New Grafting Starch Based on Triazolyl Aldehyde, Synthesis, and Antibacterial Study | ||||
| Journal of Bioscience and Applied Research | ||||
| Article 24, Volume 11, Issue 2, June 2025, Page 670-678 PDF (955.34 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbaar.2025.363077.1160 | ||||
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| Authors | ||||
| Asaad H. Aneed1; Hayder M. Kamal1; Dhurgham Aziz2; Nuha S. Kareem1; Maryam M. Mahdi3; Zahraa H. Muslim4; Zahraa H. Hamid5 | ||||
| 1Chemistry Department-Faculty of Science-University of Kufa, Najaf, Iraq | ||||
| 2College of Dentistry, Al-Muthanna University, Samawah 66001, Iraq. | ||||
| 3Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq | ||||
| 4Department of Radiology and Sonography, College of Medical Technologies, Islamic University, Najaf, Iraq | ||||
| 5ALmustaqbal University, College of Sciences, Department of Biochemistry Sciences | ||||
| Abstract | ||||
| Interest in the production of polymers with antibacterial properties is growing. In this study, a novel triazolyl aldehyde-based graftable starch was developed, and its biological activity was determined. The approach requires several steps, starting with the starch and tosyl chloride in pyridine to produce compound 2. The treatment of compound 2 with sodium azide created compound 3, containing an azide residue. Separately, compound 4 is formed by the reaction of 4-hydroxybenzaldehyde with propargyl chloride. The target product, the triazolyl aldehyde-based starch compound 5, was afforded through click chemistry by incorporating 3 and 4. All compounds were characterized using spectroscopic instruments. Finally, the antibacterial activity of grafted polymer 5 against Staphylococcus aureus and Escherichia coli was studied. | ||||
| Keywords | ||||
| Antibacterial agents; antimicrobial activity; carbohydrates; Escherichia coli; Staphylococcus aureus | ||||
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