Synthesis, Diagnoses and Biological Evaluation of New Ligand Derived from Mesalazine and acetyl isothiocyanate with their metal ion complexes | ||||
| Journal of Bioscience and Applied Research | ||||
| Articles in Press, Accepted Manuscript, Available Online from 14 May 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbaar.2025.370241.1171 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Muhammed A. Hasan Shallal1; Athmar A.Kadhim2; Hayfa A. Mubarak3; Huda Hadi Nameh4; mohauman M majeed  5
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| 1First al Mutafawiqeen School Educational Directorate Thi-Qar | ||||
| 2College of Health and Medical ,Techniques/Kufa, Al-Furat Al-Awsat Technical University/ Kufa, Najaf, Iraq. | ||||
| 3Department chemical engineering, College of Engineering, University of Babylon, Iraq | ||||
| 4College of Pharmacy , University of hilla, Babylon, Iraq | ||||
| 5kufa | ||||
| Abstract | ||||
| Mesalazine ligand (ML) having the isothiocyanate has been synthesis via reaction of mesalazine with acetyl isothiocyanate using absolute ethanol to give 5-(3-acetylthioureido)-2-hydroxybenzoic acid (ML) ligand in one step ,then the two step involved the reaction of (ML) ligand with ionic salts as Ni (II), Cu (II), Co (II), and Zn(II) via two sites for coordination (O, S) to prepared five complexes in good yield. The synthesized ( ligand and complexes) were branded using (FTIR), (1H-NMR,13CNMR), UV-vis spectroscopy and(CHNS) as well as molar conductivity , magnetic susceptibility of complexes in their solid state and atomic absorption in addition to measuring melting points. From the results we note that the molar ratio (M:L) is (1:2) for all the prepared complexes.from our results, the expected geometry for all chelating complexes is octahedral geometry. The same synthesis five complexes (ML1 - ML5 ) were measuring biological activity via two type of bacteria and appeared excellent results with compared of Ciprofloxacin drug. | ||||
| Keywords | ||||
| biological activity; isothiocyanate; mesalazine; (ML)ligand complex; ethanol | ||||
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