The Potential Protective Effects of Misoprostol Against Cardiac Damage induced by the Anticancer Drugs [Paclitaxel as an example] | ||||
| International Journal of Medical Arts | ||||
| Article 2, Volume 7, Issue 5, May 2025, Page 5653-5657 PDF (1.36 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2025.427913 | ||||
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| Authors | ||||
| Ahmed Fathi Abd El-Ghani; Ahmed Nahed Zaky | ||||
| Department of Forensic Medicine and Clinical Toxicology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. | ||||
| Abstract | ||||
| Background: Cancer is associated with increased mortality. Chemotherapeutic agents had different toxic effects. Paclitaxel, as a chemotherapeutic agent, is effective against different cancers. However, its cardiac toxicity shortens its use. The research of protective agents is continuing. Aim of the work: The study aimed to investigate the potential protective role of misoprostol against Paclitaxel -induced cardiac toxicity, besides the value of this combination for treatment of cancer. Methods: This study included 20 rats divided equally into 4 groups. The first [the control] group received 1 ml of normal saline by intraperitoneal injection and 1 ml orally for six days. The second was paclitaxel group, received 2mg/kg of paclitaxel by intraperitoneal injection at days 0, 2, 4 and 6. The third was misoprostol and received 0.2 mg/kg, dissolved in 1 ml saline daily by oral gavage for six days. The fourth group was assigned the combination [paclitaxel and misoprostol] and animals treated as in the paclitaxel and misoprostol groups. At the end, there were assessment of cardiac biomarkers [cardiac Troponin-I [cTn-I], lactate dehydrogenase [LDH] and creatine kinase-MB [CK-MB]] Tissue oxidative stress [malondialdehyde [MDA], reduced glutathione [GSH], superoxide dismutase [SOD], catalase [CAT]] biomarkers were evaluated. Results: Paclitaxel group recorded the highest cTn-I, CK-MB and LDH [1.76±0.26, 878.00±152.87 and 871.40±29.40, respectively]. However, the lower values were recorded for misoprostol [cTn-I], combination group [serum CK-Mb] and control group [serum LDH]. There was significant variance regarding oxidative stress indicators. The lowest CAT activity was obtained in Paclitaxel, then combination, misoprostol and control groups respectively [0.078±0.013, 0.080±0.018, 0.110±0.023 and 0.116±0.015 respectively]. Reduced glutathione was significantly reduced in Paclitaxel group, then misoprostol, combination and finally control group [0.150±0.015, 0.182±0.025, 0.186±0.024 and 0.203±0.021, respectively]. Conclusion: Misoprostol can protect against Paclitaxel-induced cardiotoxic effects by anti-oxidative stress and direct protective mechanisms. It does not affect the therapeutic value of paclitaxel. | ||||
| Keywords | ||||
| Cancer; Toxicity; Reactive Oxygen Species; Troponin; Prevention | ||||
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