Symptomatic and asymptomatic bacteriuria and antimicrobial susceptibility pattern among pregnant women in Kuwait | ||||
| Microbial Biosystems | ||||
| Article 3, Volume 10, Issue 2, June 2025, Page 18-29 PDF (1.18 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mb.2025.353652.1234 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Moamen Gamal Motawe Ahmed; Gamal M El-Sherbiny   ; Mohamed Kalaba ; Mohamed H. Sharaf
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| Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo 11884, Egypt, | ||||
| Abstract | ||||
| During pregnancy, physiological changes predispose women to urinary tract infections. This study aimed to evaluate the prevalence of asymptomatic bacteriuria, antimicrobial susceptibility patterns, and associated risk factors among pregnant women. Three hundred urine samples were collected from pregnant women attending Professional We Care Poly Clinic, Sabah Al-Salem area, Kuwait, between January and November 2023. Samples were cultivated on cystine lactose electrolyte deficient agar (CLED) media. Bacterial isolates were identified and antimicrobial susceptibility determined using the automated Vitek2 system and disc diffusion method on Muller-Hinton agar. The infection rate among participants was 71.33% (95% Confidence Interval (CI): 68.18-73.12%), representing 214 of 300 women. Among those examined, asymptomatic bacteriuria was identified in 51.39% (95% CI: 49.27-53.15%), corresponding to 154 cases, while symptomatic bacteriuria was observed in 19.98% (95% CI: 16.18-22.11%) of all participants. The predominant isolate was Escherichia coli (34.58%), followed by Candida sp. (17.76%), Streptococcus agalactiae (15.89%), Klebsiella pneumoniae (12.62%), and Enterococcus faecalis (11.21%). Gram-negative bacteria exhibited high resistance rates to tetracycline (96.4%) and ampicillin (90.5%). Multidrug-resistant (MDR) bacterial isolates were prevalent in 83.9% (94/112) of Gram-negative bacteria and 37.5% (42/64) of Gram-positive bacteria. Extended-spectrum beta-lactamase (ESβL) production was observed in 8.9% of Gram-negative isolates. A significant presence of bacteriuria exists in asymptomatic pregnant women, with considerable antimicrobial resistance to commonly prescribed agents. Routine screening and antimicrobial susceptibility testing are recommended for appropriate management of bacteriuria during pregnancy. | ||||
| Keywords | ||||
| Antibiotic resistance surveillance; extended-spectrum beta-lactamase (ESβL) producers; multidrug resistance (MDR); prenatal infection screening; urinary pathogens in pregnancy | ||||
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