Quinazolines and Quinazolinones as Pharmacophores: Synthetic Approaches and Biomedical Applications of Quinazolines and Their Analogies. | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 7, July 2025, Page 155-163 PDF (1.5 MB) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/ejchem.2025.362780.11345 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Huda R. M. Rashdan   1; Ewies F. Ewies 2
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| 1Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 ElBohouth St., (Former El Tahrir) Dokki, P.O. 12622, Giza, Egypt | ||||
| 2Organometallic and Organometalloid Chemistry, Chemical Industries Research Institute, National Research Centre | ||||
| Abstract | ||||
| Quinazoline and their based scaffolds can be defined as nitrogenious heterocyclic motifs with distinguished biomedical and chemical applications. Quinazoline and their derivatives comprise a family of more than 200 naturally occurred alkaloids. Recently, novel quinazolinone based molecules have been investigated, applied in designing numerous efficient protocols to produce more biomedical and pharmaceutical active scaffolds. This review evaluated the recent advanced protocols investigated for designing and synthesis quinazolines and their based scaffolds. Additionally, estimated the biomedical and therapeutical activities of these molecules. The information included in this review would assist the chemical and biomedical researches in designing novel quinazoline analogues can be considered as drug like candidates in different pharmaceutical approaches. | ||||
| Keywords | ||||
| Quinazolines; quinazolinones, biomedical applications | ||||
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