Assessment of prognostic Significance of some Blood proteins in Diagnosing Liver Cirrhosis Among Patients with Chronic Liver Disease

t Tolba Atwa Abdelfatah, Omnia Ezzat; Elkhawaga, Omali Youssef; Ibrahim, Talaat Abdallah; Hodhod, Tarek Elmoursi Ibrahim; Abdelaziz, Mohamed Mohamed

doi:10.21608/mjcc.2025.378833.1006

	Assessment of prognostic Significance of some Blood proteins in Diagnosing Liver Cirrhosis Among Patients with Chronic Liver Disease
Mansoura Journal of Chemistry
Volume 68, Issue 2, May 2025, Page 21-27 PDF (682.57 K)
Document Type: Original Article
DOI: 10.21608/mjcc.2025.378833.1006
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Authors
Omnia Ezzat t Tolba Atwa Abdelfatah ¹; Omali Youssef Elkhawaga¹; Talaat Abdallah Ibrahim²; Tarek Elmoursi Ibrahim Hodhod³; Mohamed Mohamed Abdelaziz⁴
¹Biochemistry- faculty of science- mansoura university - mansoura-Dakahlia
²Prof of General Surgery - faculty of medicine- mansoura university -Dakahlia
³Fellow of medical analyses Gisc – Masnsoura university
⁴prof of biochemistry -Gisc – Masnsoura university - mansoura-Dakahlia
Abstract
Chronic liver disease (CLD) and liver cirrhosis are two critical worldwide health problems that raise morbidity and death rates. The last stage of liver disease, cirrhosis is characterized by the replacement of healthy liver tissue with fibrotic scar tissue, which impairs liver function and causes complications like variceal bleeding, portal hypertension, ascites, and hepatic encephalopathy. The primary causes of cirrhosis are autoimmune liver diseases, nonalcoholic fatty liver disease (NAFLD), chronic viral hepatitis, and excessive alcohol use. The current study has a number of advantages and impacts It examined the most recent developments in the clinical, laboratory, and diagnostic features of liver cirrhosis patients, affording insights into the course of the medical condition and possible biomarkers for its detection and treatment. Usually, this disease progresses gradually over several months or years. The entire body is responding to the damaged liver, including the skin, brain, kidneys, gastrointestinal tract, immune system, bone marrow, heart, etc. In order to help with early diagnosis and save more lives, the current study concentrated on the most recent developments in blood-based diagnostic biomarkers to assess the diagnostic power of Mac-2 binding protein glycosylation isomer (M2BPGi) and determine the cut-off values of M2BPGi for liver cirrhosis in patients with chronic liver disease.
Keywords
chronic liver disease (CLD); hepatocellular carcinoma (HCC); nonalcoholic fatty liver disease (NAFLD); Mac-2 binding protein glycosylation isomer (M2BPGi)


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