Pattern of Pediatric Illicit Substance Intoxication at Alexandria Poison Centre: ICU Risk Assessment
Elsehly, W., Badr El Dine, F., Gamal El Dine, N., Elnwam, S., Khedr, R. (2025). Pattern of Pediatric Illicit Substance Intoxication at Alexandria Poison Centre: ICU Risk Assessment. EKB Journal Management System, 13(1), 41-54. doi: 10.21608/esctj.2025.366148.1084
Wafaa Elsehly; Fatma Badr El Dine; Nahla Gamal El Dine; sara Elnwam; Rasha Khedr. "Pattern of Pediatric Illicit Substance Intoxication at Alexandria Poison Centre: ICU Risk Assessment". EKB Journal Management System, 13, 1, 2025, 41-54. doi: 10.21608/esctj.2025.366148.1084
Elsehly, W., Badr El Dine, F., Gamal El Dine, N., Elnwam, S., Khedr, R. (2025). 'Pattern of Pediatric Illicit Substance Intoxication at Alexandria Poison Centre: ICU Risk Assessment', EKB Journal Management System, 13(1), pp. 41-54. doi: 10.21608/esctj.2025.366148.1084
Elsehly, W., Badr El Dine, F., Gamal El Dine, N., Elnwam, S., Khedr, R. Pattern of Pediatric Illicit Substance Intoxication at Alexandria Poison Centre: ICU Risk Assessment. EKB Journal Management System, 2025; 13(1): 41-54. doi: 10.21608/esctj.2025.366148.1084

Pattern of Pediatric Illicit Substance Intoxication at Alexandria Poison Centre: ICU Risk Assessment

Egyptian Society of Clinical Toxicology Journal
Volume 13, Issue 1, June 2025, Page 41-54  XML PDF (855.21 K)
Document Type: Original Article
DOI: 10.21608/esctj.2025.366148.1084
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Authors
Wafaa Elsehly1; Fatma Badr El Dine2; Nahla Gamal El Dine2; sara Elnwam3; Rasha Khedr email orcid 1
1Faculty of Medicine, Alexandria University
2Faculty of Medicine, University of Alexandria, Alexandria, Egypt
3Faculty of Medicine, University of Alexandria, Alexandria, Egypt,
Abstract
Background: Acute intoxication from illicit substances in children leads to high morbidity rates in many countries. Aim of the work: This study took an in-depth look at the patterns of acute intoxication with substances of abuse in children. Additionally, the performance of Pediatric Early Warning (PEWS) in predicting the necessity for ICU admission was investigated. Patients and Methods: A prospective observational study was conducted on children admitted to APC with a history of acute intoxication with illicit substances in the period from January 2022 to the end of June 2022.Clinical and toxicological data were collected. Pediatric early warning score (PEWS) was calculated. Results: The study involved 53 children under 18 years old. The mean age was 2.51±3.06 years. 81.1% of the children were in age group 1 - < 6 years. The largest percentage of substance intoxication was caused by cannabis (81.1%), followed by opioids (7.5%), Methanol and ethanol constituted 3.8% each, followed by benzodiazepine and methamphetamine constituted 1.9% each. The PEWS score ranged from 0-7, and 45.3% of the cases had a score of 3. The ROC curve analysis showed that a PEWS score of 4 could reliably predict the necessity for ICU care with high sensitivity and specificity. Conclusion: The PEWS score could serve as a reliable tool for predicting the need for ICU admission among acutely intoxicated pediatric patients with illicit substances. It can aid in the early identification of patients who will require ICU admission, particularly in low-income countries with limited resources.
Keywords
Illicit substance; Drug Abuse; Cannabis; Pediatric Early Warning Score; Acute Intoxication
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