The relation between Vascular Calcification in Hemodialysis Patients and Osteoporosis

sarhan, eman Ebraheim; Lotfy, Hany Hafez; Elseknedy, Mostafa Fouad Mohamed; Emara, Ahmed Abdelmonem

doi:10.21608/arcmed.2025.354825.1085

	The relation between Vascular Calcification in Hemodialysis Patients and Osteoporosis
ARCADEs of MEDICINE
Articles in Press, Accepted Manuscript, Available Online from 18 May 2025
Document Type: Original Research
DOI: 10.21608/arcmed.2025.354825.1085
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Authors
eman Ebraheim sarhan¹; Hany Hafez Lotfy²; Mostafa Fouad Mohamed Elseknedy ³; Ahmed Abdelmonem Emara¹
¹Nephrology Department, Armed Forces College of Medicine, Cairo, Egypt and at Ain shams University, Cairo, Egypt
²Radiology department, Military Medical Academy, Cairo, Egypt
³Nephrology Department, Armed Forces College of Medicine, Cairo, Egypt
Abstract
Background: Cases with end-stage renal disease who get regular hemodialysis were at a higher risk of death due to the high frequency of cardiovascular disease. The objective of the work was to assess the prevalence of osteoporosis and vascular calcification (VC) in hemodialysis individuals utilizing dual-energy X-ray absorptiometry (DEXA) scans and the aortic calcification index (ACI) and to investigate the relationship between these conditions. Methods: This cross-sectional work had been conducted on 84 patients aged >18 years old, both sexes, on regular hemodialysis using an arteriovenous fistula for more than 6 months. All patients were subjected to computed tomography abdomen and DEXA. Results: ACI was significantly greater in individuals with osteoporosis than those with normal bone density (P=0.007). Total leucocyte count and parathyroid hormone (PTH) were significantly higher in the ACI ≤ 0.25 group than ACI > 0.25 group (P=0.002). A strong negative correlation existed between ACI and both femur neck T-scores and lumbar vertebrae T-scores, which was significant (P<0.001). A strong positive correlation existed between age and ACI (P=0.012). For T-scores, a moderate negative correlation existed between femur T-scores, age (P<0.001), and PTH (P=0.001), but weak and non-significant correlations with dialysis duration, phosphorus, and calcium (P > 0.07). Conclusion: Osteoporosis, and VC present issues for hemodialysis cases, with osteoporotic individuals having higher body mass index, and PTH levels, in addition to a strong negative connection between ACI and bone mineral density.
Keywords
Vascular Calcification; Hemodialysis; Osteoporosis; Aortic Calcification Index


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