Assessment of serum B-Cell Activating Factor level as a marker of disease activity in a cohort of Egyptian patients with Inflammatory Bowel Disease
Abdelatty, K., Fawzy, M., Elsheikh, W., Elfikky, S., Nassra, R., Saad, H. (2025). Assessment of serum B-Cell Activating Factor level as a marker of disease activity in a cohort of Egyptian patients with Inflammatory Bowel Disease. EKB Journal Management System, 8(1), 1276-1287. doi: 10.21608/svuijm.2025.345484.2053
Khaled Ali Abdelatty; Moamen Ayman Fawzy; Wafaa Mohamed Hussein Elsheikh; Samar Mohamed Elfikky; Rasha Mohamed Adel Nassra; Hussein Mahmoud Hussein Saad. "Assessment of serum B-Cell Activating Factor level as a marker of disease activity in a cohort of Egyptian patients with Inflammatory Bowel Disease". EKB Journal Management System, 8, 1, 2025, 1276-1287. doi: 10.21608/svuijm.2025.345484.2053
Abdelatty, K., Fawzy, M., Elsheikh, W., Elfikky, S., Nassra, R., Saad, H. (2025). 'Assessment of serum B-Cell Activating Factor level as a marker of disease activity in a cohort of Egyptian patients with Inflammatory Bowel Disease', EKB Journal Management System, 8(1), pp. 1276-1287. doi: 10.21608/svuijm.2025.345484.2053
Abdelatty, K., Fawzy, M., Elsheikh, W., Elfikky, S., Nassra, R., Saad, H. Assessment of serum B-Cell Activating Factor level as a marker of disease activity in a cohort of Egyptian patients with Inflammatory Bowel Disease. EKB Journal Management System, 2025; 8(1): 1276-1287. doi: 10.21608/svuijm.2025.345484.2053

Assessment of serum B-Cell Activating Factor level as a marker of disease activity in a cohort of Egyptian patients with Inflammatory Bowel Disease

SVU-International Journal of Medical Sciences
Volume 8, Issue 1, January 2025, Page 1276-1287  XML PDF (281.58 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2025.345484.2053
View on SCiNiTO View on SCiNiTO
Authors
Khaled Ali Abdelatty1; Moamen Ayman Fawzy email 1; Wafaa Mohamed Hussein Elsheikh1; Samar Mohamed Elfikky1; Rasha Mohamed Adel Nassra2; Hussein Mahmoud Hussein Saad1
1Internal Medicine Department, Gastroenterology Division, Faculty of Medicine, Alexandria University, Alexandria , Egypt.
2Medical Biochemistry Department, Faculty of Medicine, Alexandria University, Alexandria , Egypt.
Abstract
Background: Diagnosis of Inflammatory Bowel Disease (IBD) requires clinical examination, serology, radiology, endoscopic and histopathological data. Employment of non-invasive biomarker with high specificity and sensitivity is needed. B-Cell activating factor (BAFF) is one of the tumor necrosis factor members. Myeloid cells are the main producers of BAFF, and its function is to regulate the survival of mature B cells and their development into plasma cells that produce antibodies.
Objectives: Our objective was to assess serum B-Cell Activating Factor level as a marker of disease activity in IBD patients.
Patients and methods: 90 patients were included, 30 Crohn’s disease (CD) patients, 30 Ulcerative Colitis (UC) patients and 30 healthy control subjects. BAFF level was measured in serum samples by enzyme-linked immunosorbent assay (ELISA). CD simple endoscopic score was used for Crohn’s disease (SES-CD) and the Crohn’s disease activity index (CDAI) and for UC Mayo score.
Results: The mean serum BAFF in CD group (8.26 ± 5.72pg/ml) and UC group (9.70 ± 8.93pg/ml) was significantly higher than in control group (3.28 ± 0.99 pg/ml) p2= 0.007, p3<0.001), and no significant difference between CD and UC group p1= 0.635. Serum BAFF correlates with inflammatory markers like Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fecal calprotectin (FC) in patients with active CD, active UC patients (p<0.001).
Conclusion: Serum BAFF could be utilized to evaluate disease activity in IBD patients as it correlates positively with disease activity indices in UC and CD. 
Keywords
Inflammatory Bowel Disease; CD; UC; Serum BAFF
Statistics
Article View: 128
PDF Download: 38