Interleukins gene polymorphism in alopecia areata patients: a systematic review | ||||
| Fayoum University Medical Journal | ||||
| Volume 15, Issue 1, April 2025, Page 34-44 PDF (767.16 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/fumj.2025.326668.1404 | ||||
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| Authors | ||||
Aliaa Ali Abd El sattar1; Nesreen Aboraia  2; Omayma Owees Abdelaleem3; Amal Talaat Abd El-Rahman4
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| 1Dermatology and Venerology department ,Faculty of medicine, Fayoum university. | ||||
| 2dermatology department fayoun university | ||||
| 3Biochemistry and Molecular Biology faculty of medicine, Fayoum University | ||||
| 4Dermatology, Faculty of medicine, Minia University | ||||
| Abstract | ||||
| Background: Alopecia areata (AA) is an autoimmune disorder that causes hair loss without scarring on the scalp or any part of the body with hair.There are various genetic variations in the interleukin genes, although the findings are inconsistent. This systematic study aimed to determine the correlation among specific genes (12B, 15, 16, 13, 12, 17A, 23, 17RA, and 18) of the interleukin family and alopecia areata. Aim and objective: The objective of this investigation is to assess the potential connection between gene variation in interleukins and a Probability of getting alopecia areata, as well as to examine its correlation with illness severity. Patients and methods: This systematic review included all relevant case-control association trials that included cases with alopecia areata & healthy controls. Conclusion: Alopecia areata is associated with IL-17A, IL-18, IL17RA, and IL16 gene polymorphisms. More genetic studies should be conducted to ensure that interleukins play a role in the progression of alopecia areata. | ||||
| Keywords | ||||
| Key words: interleukins; alopecia areata; polymorphism | ||||
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