Local GENTA-COLL Resorb Reduces Sternal Wound Infections after Cabg Surgery : A Randomized Controlled Trial

Azab, Mohamed Abdelshafy; Abdel-Rahman Shemais, Dina Said; AbdelRaouf Alsharawy, Mohamed Mamdouh; Mansour Hassan, Amr Hassan; Saeed, Sameh E

doi:10.21608/zumj.2025.384951.3953

	Local GENTA-COLL Resorb Reduces Sternal Wound Infections after Cabg Surgery : A Randomized Controlled Trial
Zagazig University Medical Journal
Volume 31, Issue 7, July 2025, Page 2597-2603 PDF (904.16 K)
Document Type: Original Article
DOI: 10.21608/zumj.2025.384951.3953
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Authors
Mohamed Abdelshafy Azab¹; Dina Said Abdel-Rahman Shemais ¹; Mohamed Mamdouh AbdelRaouf Alsharawy¹; Amr Hassan Mansour Hassan¹; Sameh E Saeed ²
¹Cardiothoracic surgery Department, Faculty of Medicine, Zagazig University, Egypt
²Department of Cardiothoracic surgery, Faculty of Medicine, Zagazig University, Egypt
Abstract
Background: In cardiac procedures, particularly CABG, post-sternotomy deep sternal wound infection (DSWI), also known as mediastinitis, can be problematic. DSWIs are extremely dangerous postoperative complications that raise hospital stays, postoperative morbidity, death, and overall medical expenses. In order to further reduce wound infections following a sternotomy, we set out to assess the effectiveness of implanted gentamicin-collagen implants (GENTA-COLL resorb). Methods: Our study was performed from May 2023 to December 2023. It included 36 high risk CABG patients for sternotomy wound infections (SWI) divided into two equal groups: GENTA-COLL and control groups. The GENTA-COLL group had local gentamycin-collagen implants inserted between sternal halves immediately before sternal closure. The control group had reinforced closure technique without gentamycin -collagen implants application. All cases were followed up for symptoms and signs of SWI. Results: Results shows increased prevalence of post sternotomy superficial wound infection among patients of control group. Purulent discharge was detected in 1 case of control group versus no cases in GENTA-COLL group, serous discharge (2 cases in control group (6.7%) versus no cases in GENTA-COLL group. As regards DSWI no cases in GENTA-COLL group versus 1 case in control group (3.3%), CT healing was much better in GENTA-COLL group rather than control group with significant statistically increase in CT healing score (p-value=0.005). Conclusion: Application of GENTA-COLL resorb possibly reduces post sternotomy superficial wound infection, prevents DSWI and improves sternal healing.
Keywords
Post-sternotomy; Infection; mediastinitis; GENTA-COLL; Local


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