Comparative Analysis of AAA and AXB Algorithms in Eclipse Treatment Planning System for Lung SBRT Radiotherapy | ||||
| International Journal of Theoretical and Applied Research | ||||
| Volume 4, Issue 1, June 2025, Page 547-552 PDF (647.72 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijtar.2025.348904.1104 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Fayza Hussein Ibrahim  1; Sahar M. Awad 2; Khaled Mohamed Elshahat 3; ola awad4
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| 1Biophysics, the faculty of science, Al Azhar university, Egypt | ||||
| 2Physics department , faculty of science , Al Azhar university | ||||
| 3Clinical oncology dept. Physics unit Faculty of Medicine Al Azhar university | ||||
| 4Department of Physics, Faculty of Science, Al-Azhar University (Girls Branch), Cairo , Egypt | ||||
| Abstract | ||||
| Stereotactic Body Radiotherapy (SBRT) is a precise treatment for lung tumors, delivering high fractional doses in a short time to improve local control and survival while reducing adverse effects. Accurate dose calculation algorithms are essential for optimizing treatment outcomes. This study compares two commonly used algorithms: Anisotropic Analytical Algorithm (AAA) and Acuros XB (AXB). AAA is known for its speed but struggles with tissue heterogeneity, while AXB is designed for better calculations in heterogeneous media, potentially enhancing lung SBRT planning. The aim of this study is to conduct a comparative analysis of the dosimetric performance of AAA and AXB within the Eclipse TPS for lung SBRT, focusing on dosimetric accuracy, plan quality, and clinical implications. The study included 20 patients with lung tumors, using CT scans imported into the Eclipse TPS. SBRT plans were generated with both algorithms using non-coplanar beams at 6 MV FFF energy. Plans were optimized to ensure target volume coverage while minimizing exposure to organs at risk (OARs). Dosimetric parameters like the Conformity Index (CI), Homogeneity Index (HI), and dose-volume histograms (DVHs) were compared. Results showed both algorithms provided acceptable dose distributions, with AAA achieving slightly higher target coverage and better homogeneity. AXB, however, demonstrated improved sparing of OARs. Both algorithms maintained clinically acceptable doses, with AXB offering better dosimetric accuracy and sparing of OARs. Future studies should focus on clinical validations of these findings. | ||||
| Keywords | ||||
| Stereotactic Body Radiotherapy (SBRT); Lung Cancer Radiotherapy; Advanced Dose Calculation Algorithm (AAA); Acuros XB Algorithm (AXB) | ||||
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