Effect of organogermanium complexes on hepatocellular carcinoma cell-line | ||||
| Arab Journal of Biotechnology | ||||
| Volume 21, Issue 2, December 2018, Page 105-114 PDF (783.63 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/arjb.2018.428799 | ||||
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| Abstract | ||||
| Organogermanium complexes are used as dietary supplement. Studies revealed that organogermanium compounds exhibited analgesic, anti-inflammatory,antioxidant, immune modulating, antiviral and anticancer activity. Ascorbic acid is an essential vitamin for human body it is well known with its antioxidant activity. High doses of ascorbic acid showed anticancer activity in different cancer cells. In this study, the effect of organogermanium compounds was tested on HEPG2 cell line. In addition, a combination of selected complexes with high dose of ascorbic acid was done. The results showed a strong antitumor activity of the newly tested compounds. A great down regulation was observed on proliferation marker Ki67 and anti-apoptotic marker BCl2 and up regulation of apoptotic marker caspase3. The combination with ascorbic acid increased the activity of some compounds acting in a synergetic way. However, other compounds showed no difference upon combination. | ||||
| Keywords | ||||
| Hepatocellular carcinoma; Organogermanium complexes; Ascorbic acid; Apoptosis | ||||
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