Effect of low-level laser therapy on cisplatin induced cytotoxicity in parotid gland of rats. | ||||
| Al-Azhar Journal of Dental Science | ||||
| Volume 28, Issue 2, April 2025, Page 239-248 PDF (3.2 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajdsm.2023.240042.1470 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
اØمد سعد سعد  1; hany abdelhamid sherif2; Abdel Nasser Awad3
| ||||
| 1Department of oral biology alazhar university Cairo boys Egypt | ||||
| 2oralbiology department alazhar university | ||||
| 3oral biology department alazhar university | ||||
| Abstract | ||||
| Objective: the current study was designed to evaluate the therapeutic efficacy of low-level laser therapy (LLLT) on parotid glands following cytotoxicity produced by cisplatin in rats. Subject and Methods: The study employed a sample of 36 adult males Sprague-Dawley rats were divided into three groups, each consisting of 12 rats. Group I: control group received phosphate-buffered saline. Group II: referred to as the cisplatin group, was administered a solitary intraperitoneal injection of the cisplatin medication at a dosage of 10mg/kg. Group III: received the dose of cisplatin used in group II, then exposed to a single session of LLLT on day 3 after cisplatin administration. After cisplatin injection and low-level laser irradiation, animals were sacrificed at 7 and 14 days. The sacrifice was examined histologically and ultra structurally. Results: The experimental LLL-treated group showed some improvement in the gland but could not regenerate to normal arctecture. Conclusion: This study proved that LLL cannot improve cytotoxicity induced by cisplatin in parotid glands. | ||||
| Keywords | ||||
| parotid glands; cisplatin; low level laser | ||||
|
Statistics Article View: 74 PDF Download: 49 |
||||
