Design, Synthesis, Characterization, and Evaluation of Anti-inflammatory Activity of Amino thiazole Coumarin Derivatives
Adsule, P., Purandare, D., Chabukswar, A., Raut, K., Kulkarni, S. (2025). Design, Synthesis, Characterization, and Evaluation of Anti-inflammatory Activity of Amino thiazole Coumarin Derivatives. EKB Journal Management System, 68(13), 1265-1275. doi: 10.21608/ejchem.2025.337094.10820
Prajakta Adsule; Dishank Purandare; Anuruddha Chabukswar; Kunal Raut; Shreya Kulkarni. "Design, Synthesis, Characterization, and Evaluation of Anti-inflammatory Activity of Amino thiazole Coumarin Derivatives". EKB Journal Management System, 68, 13, 2025, 1265-1275. doi: 10.21608/ejchem.2025.337094.10820
Adsule, P., Purandare, D., Chabukswar, A., Raut, K., Kulkarni, S. (2025). 'Design, Synthesis, Characterization, and Evaluation of Anti-inflammatory Activity of Amino thiazole Coumarin Derivatives', EKB Journal Management System, 68(13), pp. 1265-1275. doi: 10.21608/ejchem.2025.337094.10820
Adsule, P., Purandare, D., Chabukswar, A., Raut, K., Kulkarni, S. Design, Synthesis, Characterization, and Evaluation of Anti-inflammatory Activity of Amino thiazole Coumarin Derivatives. EKB Journal Management System, 2025; 68(13): 1265-1275. doi: 10.21608/ejchem.2025.337094.10820

Design, Synthesis, Characterization, and Evaluation of Anti-inflammatory Activity of Amino thiazole Coumarin Derivatives

Egyptian Journal of Chemistry
Volume 68, Issue 13, December 2025, Pages 1265-1275    PDF (783.38 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2025.337094.10820
Authors
Prajakta Adsule1; Dishank Purandare* 2; Anuruddha Chabukswar1; Kunal Raut1; Shreya Kulkarni1
1School of Health Sciences & Technology, Dr. Vishwanath Karad MIT World Peace University, Pune, Department of Pharmaceutical Sciences, Pune – 411038
2School of Health Sciences and Technology, Department of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune - 411038
Abstract
This research aims to design, synthesize, and assess the in-vitro anti-inflammatory activity of aminothiazole coumarin derivatives by reacting 3-bromoacetyl coumarin with thiourea in ethanol to give 5 substituted coumarin derivatives. The synthesized compounds were designed & evaluated to investigate their binding interactions with the protein target 3PGH. All the newly synthesized aminothiazole coumarin derivatives are characterised by IR, 1H NMR and mass spectroscopy. Compounds were evaluated for in-vitro anti-inflammatory activity by using membrane stabilization assay & BSA denaturation assay, measuring their ability to modulate key markers of inflammation. Compounds 5b, 5c and 5e exhibited significant activity and Compound 5d showed moderate activity by membrane stabilization assay. Compound 5c exhibited significant activity & Compound 5c showed moderate activity by BSA denaturation assay. Compounds 5b and 5c are found to exert significant anti-inflammatory activity by membrane stabilization assay as well as BSA denaturation assay and can serve as potential compounds as anti-inflammatory agents to treat inflammation in future.
Keywords
Anti-inflammatory; Coumarin; diclofenac; Cell-based assay; Molecular Docking
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