Evaluation of fecal calprotectin in patients with juvenile polyps before and after polypectomy | ||||
| African Journal of Gastroenterology and Hepatology | ||||
| Volume 8, Issue 1, 2025, Page 74-88 PDF (469.42 K) | ||||
| Document Type: Scientific Research | ||||
| DOI: 10.21608/ajgh.2025.363399.1077 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohammed Abdel-Hafez Ali   1; Hossam A. Galbt2; Ayman Ahmed Sakr3
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| 1Pediatric hepatology, gastroenterology and nutrition - National Liver Institute- Menoufia University, Egypt | ||||
| 2Clinical Pathology, National Liver Institute, Menoufia University, Egypt | ||||
| 3Tropical Medicine Department, Faculty of Medicine, Menoufia University, Egypt | ||||
| Abstract | ||||
| Background: Juvenile polyps are common in children and are usually asymptomatic, but can cause symptoms like rectal bleeding and abdominal pain. Monitoring for recurrence and using biomarkers like fecal calprotectin (FCP), which helps assess inflammation, are essential for management. These polyps may also increase the risk of colorectal cancer, especially in juvenile polyposis syndrome. Further research is needed to understand the role of fecal calprotectin before and after polyp removal. The aim was to investigate the levels of fecal calprotectin in children and adolescents with juvenile polyps before and after polypectomy. Patients and methods: A prospective cohort study was conducted from January 2019 to March 2022, which included fifty children and adolescents, aged 1 to 18 years, diagnosed with juvenile polyps through colonoscopy. Patients were recruited from the Pediatric Hepatology Department at the National Liver Institute and the Tropical Medicine Department of the Faculty of Medicine, Menoufia University. They were followed for an additional six months. Results: Fifty pediatric patients with juvenile polyps were found, with most aged 5-10 years (50%), followed by those under 5(38%) and 10-18 years (12%), with a mean age of 6.91 years. Of the patients, 46% had multiple polyps, 50% had pedunculated polyps, and 24% had sessile polyps. Larger polyps (20 mm vs. 12 mm) and pedunculated polyps were linked to higher FCP levels, while age and solitary polyps were not. Conclusion: FCP can be a valuable marker for evaluating disease severity and monitoring response to treatment in pediatric patients with juvenile polyps. | ||||
| Keywords | ||||
| Juvenile polyps; fecal calprotectin; colonoscopy | ||||
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