Combined Liquid Nitrogen and Subchondral Bone Graft in Giant Cell Tumor of Bone around Knee Joint: a Prospective Study | ||||
| The Egyptian Orthopaedic Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 21 May 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eoj.2025.372107.1022 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
mena nashat ibrahem  1; Mohammed Hegazy2; Sherif Azmy 3; Ahmed Shaban Hassan4
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| 1Helwan university | ||||
| 2Benha University | ||||
| 3Ain Shams University | ||||
| 4Department of Orthopedic Surgery, Faculty of Medicine, Helwan University, Helwan, Egypt. | ||||
| Abstract | ||||
| Background: GCTB develops in the epiphyseo-metaphyseal regions of the limbs, with approximately 50–65% of cases occurring near the knee joint. The optimal therapeutic approach must effectively manage the tumor while preserving limb functionality. Curettage remains the primary surgical approach for most GCTB cases with very high local recurrence rates (25– 50%) . In GCTB treatment, according to literatures using physical or chemical techniques including high-speed burr , ethanol , phenol , and liquid nitrogen , among other adjuvant techniques. Subsequently, bone defects are reconstructed using cement to enhance stability and lower the risk of tumor reappearance. Aim of Work: To measure the recurrence rate and osteoartheritis after using combined technique of liquid nitrogen and impaction subchondral grafting in cases with GCTB around knee joint. Patients and methods: This is a prospective study was performed in the Orthopedic Department at Ain Shams university hospital and Fared Habib hospital from November 2020 to October 2024 involving 22 patients with GCTB around knee joint all treated by extended curettage, high speed burring, liquid nitrogen, cancellous impacted subchondral bone graft, cementation or fibular grafts with or without hardware fixation. Results: They were 12 females (54.5 %) and 10 males (45.5%) aged between 25 to 50 years. The mean follow-up spanned 31 months (18 - 48 months). Conclusion: Individuals with GCTB adjacent to the knee joint can be managed successfully with using liquid nitrogen,subchondral iliac bone graft and cement or fibular graft filling. Cement filling with subchondral iliac bone graft dose not induce osteoarthritis | ||||
| Keywords | ||||
| Giant Cell Tumor; Liquid Nitrogen; Subchondral Bone Graft | ||||
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