Evaluation of anti-cytogenotoxic potential of Atriplex portulacoides crude extract in mice bone marrow. | ||||
| Damietta Journal of Agricultural Sciences | ||||
| Volume 4, Issue 2, July 2025, Page 116-122 PDF (910.03 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/djas.2025.429289 | ||||
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| Authors | ||||
Mohamed Saad Hamada1; Mohammed Hassan H. Abd El-Aziz 2; Neima Koutb Alsenosy3; Doaa Hassan Eltelet  1
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| 1Agric. Biotechnology Department, Faculty of Agriculture, Damietta University, Egypt | ||||
| 2Genetics Department, Faculty of Agriculture, Mansoura University, Egypt | ||||
| 3Genetics Department, Faculty of Agriculture, Ain shams University, Egypt | ||||
| Abstract | ||||
| Medicinal plants are essential to traditional medical systems because they are abundant in biologically active compounds that support the physiological and biochemical functions of living organisms. Among these actions, anti-cytogenotoxic qualities are particularly noteworthy, as they offer protection against cytogenotoxicity caused by unfavorable environmental conditions. Our current study evaluates the anti-cytogenotoxic properties of the crude extract of A. portulacoides by assessing the rates of aberrant mitosis in mice bone marrow. Mice were administered 5 mg/kg body weight of A. portulacoides crude extract three times a week for two weeks before receiving mitomycin C (MMC). A separate group of mice received MMC alone as a positive control. The findings demonstrated that exposure to MMC statistically significantly increased chromosomal abnormalities compared to the control group. While, pre-treatment with A. portulacoides crude extract resulted in a significant reduction in the MMC-induced rate of both structural and numerical chromosomal aberrations and increased the mitotic index. Overall, our results suggest that the A. portulacoides crude extract could be a protective food supplement and a promising agent to reduce the cytogenotoxicity effects that may result from anticancer drugs. However, further study is necessary to confirm these potential benefits. | ||||
| Keywords | ||||
| Medicinal plants; mitomycin C; anti-cytogenotoxic | ||||
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