Gene Expression Variations of mirRNA US5-1 in Cytomegalovirus and mirRNA181a in Humans and Their Use as Prognostic Factors for the Risk of Miscarriage in Women in Diwaniyah Governorate, Iraq
Abdulrab, A., Al-Ramahy, S., Al-Harmooshee, M. (2025). Gene Expression Variations of mirRNA US5-1 in Cytomegalovirus and mirRNA181a in Humans and Their Use as Prognostic Factors for the Risk of Miscarriage in Women in Diwaniyah Governorate, Iraq. EKB Journal Management System, 34(3), 459-465. doi: 10.21608/ejmm.2025.379110.1589
Athraa A. Abdulrab; Syoof K. Al-Ramahy; Maather B.H. Al-Harmooshee. "Gene Expression Variations of mirRNA US5-1 in Cytomegalovirus and mirRNA181a in Humans and Their Use as Prognostic Factors for the Risk of Miscarriage in Women in Diwaniyah Governorate, Iraq". EKB Journal Management System, 34, 3, 2025, 459-465. doi: 10.21608/ejmm.2025.379110.1589
Abdulrab, A., Al-Ramahy, S., Al-Harmooshee, M. (2025). 'Gene Expression Variations of mirRNA US5-1 in Cytomegalovirus and mirRNA181a in Humans and Their Use as Prognostic Factors for the Risk of Miscarriage in Women in Diwaniyah Governorate, Iraq', EKB Journal Management System, 34(3), pp. 459-465. doi: 10.21608/ejmm.2025.379110.1589
Abdulrab, A., Al-Ramahy, S., Al-Harmooshee, M. Gene Expression Variations of mirRNA US5-1 in Cytomegalovirus and mirRNA181a in Humans and Their Use as Prognostic Factors for the Risk of Miscarriage in Women in Diwaniyah Governorate, Iraq. EKB Journal Management System, 2025; 34(3): 459-465. doi: 10.21608/ejmm.2025.379110.1589

Gene Expression Variations of mirRNA US5-1 in Cytomegalovirus and mirRNA181a in Humans and Their Use as Prognostic Factors for the Risk of Miscarriage in Women in Diwaniyah Governorate, Iraq

Egyptian Journal of Medical Microbiology
Volume 34, Issue 3, July 2025, Page 459-465  XML PDF (353.29 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2025.379110.1589
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Authors
Athraa A. Abdulrab email 1; Syoof K. Al-Ramahy2; Maather B.H. Al-Harmooshee3
1Al-Furat Al-Awsat Technical University, Technical Institute, Diwanya, Iraq
2Department of Biology, Faculty of Sciences, University of Al- Qadisiyah, Iraq
3Department of Pathology, College of Medicine, University of Al Qadisiya, Diwaniyah, Iraq
Abstract
Background: Human cytomegalovirus (HCMV) can cause serious complications in pregnant women and their fetuses. Objective: the aim of this works is to study the gene expression role of miRNAUS5-1 and miRNA181a in women with HCMV-associated miscarriages. Methodology:  From January 2024 and September 2024, 50 healthy participants and 50 patients with miscarried were enrolled in this study at of the Maternity and Children's Hospital.  The real-time polymerase chain reaction (RT-PCR) test was used to test viral microRNA and human microRNA to detect genetic differences in their expression in women with HCMV-associated miscarriages. Results: Aborted women with CMV levels of miRNA-181a were substantially higher (P<0.05) than those of control participants, while the mean expression of mir-US5-1 gene in women who had miscarriages due to CMV was 5.49 ± 1.20, this gene was not expressed in the healthy control group Conclusion: Our results proved that there was an important immunological role of gene expression in women with HCMV-associated miscarriages.
Keywords
mirRNAUS5-1; mirRNA 181a; miscarriage; Human cytomegalovirus
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