Clinical and Radiographical Evaluation of Platelet Rich Fibrin Mixed with Nanocrystalline Hydroxyapatite Bone Graft for Healing of Maxillary Bony Defects | ||||
| Dental Science Updates | ||||
| Article 1, Volume 6, Issue 2, September 2025, Page 203-217 PDF (2.96 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/dsu.2025.355430.1284 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Yahia Ahmed Mohamed Naguib Aboulazm1; Mohamed Said Hamed2; Ahmad Mohamed Elrawdy 3; Ahmed Abdelmohsen Younis Ahmed Ali  4
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| 1Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt | ||||
| 2Oral and Maxillofacial surgery, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt. | ||||
| 3Department of Oral Radiology, Fcaulty of Dentistry, Suez Canal University | ||||
| 4oral and Maxillofacial Surgery, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt | ||||
| Abstract | ||||
| Introduction: Platelet Rich Fibrin (PRF) combined with Nanocrystalline Hydroxyapatite bone graft offers a promising approach for enhancing bone regeneration in maxillary bony defects. Aim: To evaluate postoperative clinical and radiographic outcomes of maxillary intrabony defects using a mix of nanocrystalline hydroxyapatite (nHA) bone graft with platelet rich fibrin (PRF) after removal of maxillary cystic lesions. Materials and Methods: Sixteen patients necessitating the surgical removal of intra-bony cystic lesions were enrolled in a randomized controlled investigation and subsequently allocated to one of two study arms. Eight patients, forming the control cohort (Group I), underwent conventional healing without the use of grafting materials following surgical excision of the cystic lesions. In contrast, the study cohort (Group II), also comprising eight patients, received a graft composed of nanocrystalline hydroxyapatite and platelet-rich fibrin following lesion removal. Results: Analysis of the collected data demonstrated a statistically significant lower pain score in study group in the seventh day (p = 0.012). The study group showed a more rapid resolution of edema compared to the control group, although differences between groups at individual time points did not reach statistical significance (p = 1.000). Notably, the study group exhibited a highly statistically significant increase in bone density at the T1 time interval compared to the control group (P < 0.001). In contrast, baseline bone density measurements (T0) showed no statistically significant disparity between the two groups (P = 0.466). No Postoperative complications for both groups as infection, wound dehiscence, or looseness of adjacent teeth at 1-, 7-, and 14-days post-operative. Conclusion: PRF combined with nanocrystalline hydroxyapatite may be considered a potential material for promoting bone repair following the enucleation of maxillary cystic lesions. | ||||
| Keywords | ||||
| Platelet Rich Fibrin; Nanocrystalline Hydroxyapatite Bone Graft; Maxillary Bony Defects | ||||
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