Aromatase Inhibitory Profile of Novel Tetrabromoisoindoline Derivatives | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 11, November 2025, Pages 87-95 PDF (398.88 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2025.370924.11505 | ||
| Authors | ||
| Ahmed ElRashedy1; Mahmoud Nabil Mahmoud Yousif* 2; Nabil Yousif3; Noha El-Sayed Ibrahim4 | ||
| 1Natural and Microbial chemistry Department , National Research Center, Egypt | ||
| 2Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Cairo, Egypt | ||
| 3Photochemistry Department, National Research Centre, Egypt | ||
| 4Microbial biotechnology Dept., National Research Centre | ||
| Abstract | ||
| Tetrabromophthalic anhydride reacts with p-amino benzoates namely p-amino methyl benzoate and p-amino ethyl benzoate to afford isoindoline derivatives 1a,b. Also, isoindoline derivative 1a reacts with hydrazine hydrate to form benzohydrazide derivative 2. Compound 2 reacts with different aromatic aldehydes namely p-chloro benzaldehyde, p-floro benzaldehyde, and p-N,N-dimethylamino benzaldehyde to afford isoindoline derivatives 3a-c. Benzohydrazide derivative 2 reacts with ribose, and glucose to form isoindoline derivatives 4a,b. Compounds 4a,b is acetylated with acetic anhydride to give acetylated sugar derivatives 5a,b. Benzohydrazide derivative 2 reacts with potassium thiocyanate to afford triazole derivative 6. Isoindoline derivative 6 reacts with chloroacetyl chloride to afford thiazole derivative 7 which reacts with p-chlorobenzaldehyde to form isoindoline derivative 8. Isoindoline derivative 2 reacts with carbon disulfide to afford carbodithioate 9 which interacts with hydrazine hydrate to afford triazole derivative 10. Trizole derivative 10 reacts with p-chlorobenzaldehyde to afford isoindoline derivative 11. Benzohydrazide derivative 2 reacts with iosthiocyanate derivatives namely benzylisothiocyanate and phenyl isothiocyanate to give triazole derivative 12a,b. Aromatase inhibitory effect, and cytotoxic effect against T47D, and MRC-5 of isoindoline derivatives 1a,b-12a,b were reported. | ||
| Keywords | ||
| Aromatase inhibitory activity; tetrabromoisoindoline; Tetrabromophthalic anhydride; triazole; dioxoisoindoline; T47D | ||
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