Aromatase Inhibitory Profile of Novel Tetrabromoisoindoline Derivatives | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 11, November 2025, Page 87-95 PDF (264.33 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2025.370924.11505 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ahmed ElRashedy 1; Mahmoud Nabil Mahmoud Yousif  2; Nabil Yousif3; Noha El-Sayed Ibrahim4
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| 1Natural and Microbial chemistry Department , National Research Center, Egypt | ||||
| 2Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Cairo, Egypt | ||||
| 3Photochemistry Department, National Research Centre, Egypt | ||||
| 4Microbial biotechnology Dept., National Research Centre | ||||
| Abstract | ||||
| Tetrabromophthalic anhydride reacts with p-amino benzoates namely p-amino methyl benzoate and p-amino ethyl benzoate to afford isoindoline derivatives 1a,b. Also, isoindoline derivative 1a reacts with hydrazine hydrate to form benzohydrazide derivative 2. Compound 2 reacts with different aromatic aldehydes namely p-chloro benzaldehyde, p-floro benzaldehyde, and p-N,N-dimethylamino benzaldehyde to afford isoindoline derivatives 3a-c. Benzohydrazide derivative 2 reacts with ribose, and glucose to form isoindoline derivatives 4a,b. Compounds 4a,b is acetylated with acetic anhydride to give acetylated sugar derivatives 5a,b. Benzohydrazide derivative 2 reacts with potassium thiocyanate to afford triazole derivative 6. Isoindoline derivative 6 reacts with chloroacetyl chloride to afford thiazole derivative 7 which reacts with p-chlorobenzaldehyde to form isoindoline derivative 8. Isoindoline derivative 2 reacts with carbon disulfide to afford carbodithioate 9 which interacts with hydrazine hydrate to afford triazole derivative 10. Trizole derivative 10 reacts with p-chlorobenzaldehyde to afford isoindoline derivative 11. Benzohydrazide derivative 2 reacts with iosthiocyanate derivatives namely benzylisothiocyanate and phenyl isothiocyanate to give triazole derivative 12a,b. Aromatase inhibitory effect, and cytotoxic effect against T47D, and MRC-5 of isoindoline derivatives 1a,b-12a,b were reported. | ||||
| Keywords | ||||
| Aromatase inhibitory activity; tetrabromoisoindoline; Tetrabromophthalic anhydride; triazole; dioxoisoindoline; T47D | ||||
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