Clinical and laboratory profile of patients with Acute-on- Chronic Liver Failure | ||
| Aswan University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 26 May 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aumj.2025.376826.1228 | ||
| Authors | ||
| Mina Tharwat1; Heba Ramdan Ahmed* 1; Sahar Hassany2 | ||
| 1Department of Gastroenterology and Tropical Medicine, Faculty of medicine, Aswan university | ||
| 2Department of Gastroenterology and Tropical Medicine, Faculty of medicine, Assiut university | ||
| Abstract | ||
| Abstract Background: Acute-on-chronic liver failure (ACLF) is a life-threatening clinical syndrome that develops in patients with acute deterioration of chronic liver disease. We aimed to evaluate the clinical and laboratory profile of patients with ACLF at Aswan university hospital. Methods: This prospective study was carried out on 128 patients, 20 patients were lost to follow up. Patients were further divided into two groups: survivors group (n= 70) and non survivors group (n=38) based on 28-day follow up. All patients underwent full medical history and clinical examination [Demographics, reason for admission, hospitalization in prior 6 months, admission medication, cause of liver cirrhosis, type of decompensation, clinical data suggestive of chronic liver cell failure, and vital signs], and laboratory investigations [Kidney and liver function tests, coagulation profile, arterial blood gas, and serum electrolytes] were obtained for all patients. Results: There was statistically significant increase in values of hepatic encephalopathy grades, total leucocytes count, serum creatinine, serum bilirubin, INR, pulse rate and respiratory rate, in non survivors group compared to the survivors; while there was significant decrease in pH, HCO3, oxygen saturation and blood pressure in the non-survivors compared to the survivors (P<0.05). Conclusions: Decreased oxygen saturation, HCO3, blood pressure along with increased pulse rate, respiratory rate, serum creatinine, serum bilirubin, INR, total leucocytes count, presence of encephalopathy are independent predictors of mortality, reflecting the severity of underlying liver insufficiency, kidney dysfunction, hemodynamic and respiratory instability. Therefore, they can be used to predict mortality risk. Keywords: In-hospital mortality, cirrhosis, Acute-on-Chronic Liver Failure; predictors | ||
| Keywords | ||
| Keywords: In-hospital mortality, cirrhosis, Acute-on-Chronic Liver Failure; predictors | ||
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