Effect of Natural Probiotics on the Enterally Fed Critically Ill Patients’ Outcomes | ||||
| Alexandria Scientific Nursing Journal | ||||
| Volume 27, Issue 2, June 2025, Page 211-227 PDF (369.96 K) | ||||
| Document Type: Research articles | ||||
| DOI: 10.21608/asalexu.2025.429970 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Nagwa Ahmed Reda1; Nermeen Farouk Abdel All Elsayed* 2; Mohamed Mostafa Abd Elsalam Megahed3; Eman Arafa Hassan Ali4 | ||||
| 1Professor Emeritus Critical Care and Emergency Nursing, Faculty of Nursing, Alexandria University. | ||||
| 2Clinical Instructor Critical Care and Emergency Nursing, Faculty of Nursing, Alexandria University | ||||
| 3Professor Critical Care Medicine, Critical Care Medicine Department, Faculty of Medicine, Alexandria University. | ||||
| 4Assistant Professor Critical Care and Emergency Nursing, Faculty of Nursing, Alexandria University. | ||||
| Abstract | ||||
| Background: The management of critical illness in the contemporary intensive care units (ICUs) creates an adverse environment in the gut of the critically ill and alters the microbiome. Numerous endogenous and iatrogenic factors causing a state of dysbiosis, which is the state of microbiome imbalance, this leading to translocation of pathogens and facilitate the emergence of systemic inflammatory response (SIRS), sepsis, and multiple organ dysfunction syndrome (MODS). It should come as no surprise that the gut is the primary source and contributor of nosocomial sepsis and MODS in critically ill patients, which is the main factor affecting the prognosis of patients in the ICUs. In order to restore the homeostasis of the microbiome, several nutritional strategies have been evaluated with the aim to improve the outcomes, including probiotics that are currently being used. Because the positive benefits of probiotics in several clinical trials, the understanding of how probiotics enhance the outcomes of enterally fed critically ill patents is therefore crucial. Objective: To identify the effect of natural probiotics on the enterally fed critically ill patients’ outcomes. Settings: This study was conducted in the general ICUs at Alexandria Main University Hospital, unit I (11 beds), unit II (12 beds), and unit III (16 beds). Subjects: a convenience sample of 60 newly admitted mechanically ventilated adult patients who started orogastric or nasogastric tube feeding within the 24 to 48 hours from admission. Tools: One tool was used to collect the data in this study namely "Probiotics and non-probiotics enterally fed critically ill patients’ assessment record". Results: Findings of the present study illustrated significant reduction in the incidence of VAP (P=0.020), ICU length of stay and mortality rate (P=0.023). However, this intervention had a minimal impact on the other variables with no significant statistical difference between both groups, in relation to vomiting, diarrhea, feeding intolerance, constipation, UTI, and the duration on mechanical ventilation among enterally fed critically ill patients (P=1.000, 0.371, 0.371, 0.080, 0.559, 0.706 respectively). Conclusion: The present study concluded that administration of natural probiotics to enterally fed critically ill patients seemed to confirm positive outcomes. Recommendations: Adopt the use of the natural probiotics for the enterally fed critically ill patients in the ICUs. Conduct more trials to identify the optimum bacterial strain, timing, duration, and dosing for each health problem. | ||||
| Keywords | ||||
| Probiotics; Enterally Fed; Critically Ill Patients; Outcomes | ||||
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