Association of Interleukin 15 Serum Level with Different Clinical Severities of Acne Vulgaris | ||||
| Suez Canal University Medical Journal | ||||
| Article 7, Volume 28, Issue 5, May 2025, Page 0-0 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/scumj.2025.345509.1642 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mai Samra  1; Amal Gomaa1; Ranya Hassan2; Lina Atef 3
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| 1Dermatology, Venerology and Andrology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||||
| 2Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||||
| 3Venerology and Andrology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||||
| Abstract | ||||
| Background: Acne is a chronic inflammatory disease of the pilosebaceous units with multifactorial pathogenesis. Interleukin 15 (IL-15), is a protein linked to various autoimmune and inflammatory disorders. Aims: To assess the concentration of IL-15 in the blood of individuals with acne vulgaris, comparing patients with varying degrees of acne severity to healthy individuals without acne. Materials and Methods: The research involved 40 individuals diagnosed with acne vulgaris and 40 healthy participants as a control group. Blood samples were taken from both the acne patients and the control group to measure IL-15 levels using a test called ELISA. Results: No significant difference was noted between acne patients and control groups regarding serum IL-15. The diagnostic accuracy of IL15 expression in prediction of sever mild cases is good, confidence interval (CI%) (51% – 90%) and p value =0.039 at a cut-off value of IL15 level of > 43 ng/ml. The diagnostic accuracy of IL15 expression in prediction of sever and very severe cases is good, CI% (55% – 96%) and p value =0.025 at a cut-off value of IL15 level of ≤ 42 ng/ml. There was a significant moderate negative correlation between serum IL-15 and the acne score (r= -0.477, p= 0.002). No significant correlation was noted between the serum biomarker and either of age, age of onset, or disease duration. Conclusions: As acne became more severe, the levels of IL-15 in the blood significantly decreased. This suggests that IL-15 may play a role in how acne develops and progresses. | ||||
| Keywords | ||||
| Inflammatory Disorders; Acne Vulgaris; Interleukin-15; Hair Follicles; Sebaceous Glands | ||||
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