Evaluation of antimicrobial activity of 5-(4-aminophenyl)-1,3,4-thiadiazol-2- amine | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 27 May 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2025.385178.2792 | ||||
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| Authors | ||||
Ban M. Saeed  1; Farqad M. Alhamdani* 1; Alyaa S. Jasim* 2; Shaker A.N. Al-Jadaan* 3; Basil A. Abbas* 4
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| 1Department of Microbiology, Al-Zahraa College of Medicine, University of Basrah, Basrah, Iraq | ||||
| 2Department of Microbiology, College of Veterinary Medicine, University of Basrah , Basrah, Iraq | ||||
| 3Department of Pharmaceutical Chemistry, College of Pharmacy , University of Basrah, Basrah, Iraq | ||||
| 4Department of Microbiology, College of Veterinary Medicine, University of Basrah, Basrah, Iraq | ||||
| Abstract | ||||
| Background: Due to multidrug resistance and the broad spectrum of biological features of the medicinal chemistry, this study examined the activity of antibacterial molecule (thiadiazole) using gram (+ve) and gram (-ve) bacteria and many fungal species. Methods: This study was began from December 2020 to July 2023. The study included synthesis of a thiadiazol compound from reaction between (5gm, 0.036 mol.) 4-hydroxybenzoic acid with (3.32gm, 0.036 mol.) of thiosemicarbazide in the presence of concentrated sulphuric acid. The biological efficacy of the thiadiazol compound had been evaluated at 80, 60, and 40 mg/ml among four bacterial species included Bacillus cereus (MK468691), Staphylococcus aureus, Escherichia coli and Proteus spp and against fungal isolates included Candida albicans and Pencillium sp. The four bacterial species, and fungal isolates were subjected to the MIC test (20, 15, 10, 5, 4, 2, 0.8 and 0.7 mg/ml), respectively to examine their response to the thiadiazol. Results: The synthesized compound had antimicrobial activity against several types of bacteria and fungi in different concentrations, so the MIC for Escherichia coli , Staphylococcus aureus were 0.8, 2mg/ml, respectively, while the MIC for Bacillus cereus and Proteus were 5 mg/ml for each one. In addition, this compound had inhibition activity for Candida albicans as well as Pencillium and its MIC for these fungi were 2, 4 mg/ml, respectively. Conclusion: The synthesized thiadiazol material had very good antimicrobial action among some pathogenic bacteria and fungi. This chemical compound can be utilized as an antibiotic with a narrow spectrum. | ||||
| Keywords | ||||
| thiadiazole compound; antimicrobial activity; amine; antibacterial activity; antifungal activity | ||||
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