IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLIN D1 IN ENDOMETRIAL CARCINOMA.
Elsheikh, S., Elshazly, M., Abdel Aziz, M., Saied, A. (2025). IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLIN D1 IN ENDOMETRIAL CARCINOMA.. EKB Journal Management System, 7(2), 56-57. doi: 10.21608/alexpo.2025.390338.2185
Samar Mohamed Elsheikh; Mohamed Farouk Elshazly; Marwa Mohamed Abdel Aziz; Aya Mohamed Saied. "IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLIN D1 IN ENDOMETRIAL CARCINOMA.". EKB Journal Management System, 7, 2, 2025, 56-57. doi: 10.21608/alexpo.2025.390338.2185
Elsheikh, S., Elshazly, M., Abdel Aziz, M., Saied, A. (2025). 'IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLIN D1 IN ENDOMETRIAL CARCINOMA.', EKB Journal Management System, 7(2), pp. 56-57. doi: 10.21608/alexpo.2025.390338.2185
Elsheikh, S., Elshazly, M., Abdel Aziz, M., Saied, A. IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLIN D1 IN ENDOMETRIAL CARCINOMA.. EKB Journal Management System, 2025; 7(2): 56-57. doi: 10.21608/alexpo.2025.390338.2185

IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLIN D1 IN ENDOMETRIAL CARCINOMA.

ALEXMED ePosters
Article 1, Volume 7, Issue 2, April 2025, Pages 56-57
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2025.390338.2185
Authors
Samar Mohamed Elsheikh1; Mohamed Farouk Elshazly2; Marwa Mohamed Abdel Aziz3; Aya Mohamed Saied* 4
1Department of pathology Alexandria university
2Department of clinical oncology Alexandria university
3Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University
4Department of pathology faculty of medicine
Abstract
EC is considered as one of the most common malignant tumors of the female reproductive tract. EC is most typically diagnosed after menopause, with a peak incidence of 60 to 70 years. Risk factors include obesity, nulliparity, hormonal imbalance and genetic predisposition. Molecular classification of EC includes POLE mutated type, hypermutated type with MSI instability and p53 mutant type. Prognostic factors of EC include: stage and its parameters, endometrial thickness, p53 status, MMR status.The tumor stage is determined by: Histological subtype and grade, Uterine serosal involvement, Adnexal involvement, Parametrial invasion, Myometrial invasion, Cervical stromal invasion, Vaginal involvement, Lymphovascular space invasion (LVI) andLymph node involvement. Cyclin D1 is a crucial regulator of cell cycle progression and participates in DNA synthesis. Cyclin D1 regulates the G1-S phase transition by both CDK-dependent and CDK-independent pathways. During cell cycle progression most oxidative DNA lesions occurring in the G1 phase are repaired by MMR proteins. Persistent expression of cyclin D1 during S-phase increases the mutational burden and promotes microsatellite instability due to inability of MMR proteins to bind to PCNA, persistently occupied by p21.
Keywords
Endometrial; cyclin D1; Mismatch repair
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