Effect of Adding L-Carnitine to Clomiphene Resistant PCOs Women on the Ovulation and the Pregnancy Rate | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 15, Volume 76, Issue 5, July 2019, Pages 4138-4143 PDF (368.17 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2019.43079 | ||
| Authors | ||
| Ahmed Taha Abd-Elfattah* 1; Fahd Abd El-aal Elomda1; Mahmoud Abd-Ellatif Hashish2; Hossam Ibrahim Megahed1 | ||
| 1Departments of Obstetrics & Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| 2Departments of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Background: polycystic ovary (PCO) syndrome is an endocrionologic disorder that affecting about 6-10% of women in their reproductive age. Conception rate with clomiphene citrate treated cycles is about 40% only and the number of ovulated oocyte decrease significantly with repeated cycles of ovulation. Objective: evaluation of the effectiveness of usage of clomiphene citrate with L-carnitine (LC) in induction of ovulation in clomiphene citrate resistant patients. Patients and Methods: Randomized controlled study included a total number of 50 women with clomiphene-resistant PCOs. They were divided into 2 groups, group (A) where patients received 100 to 150 mg clomiphene citrate from day three until day seven of the cycle and L-carnitine (LC) 3g daily till positive pregnancy test and group (B) received 100 to 150 mg clomiphene citrate with placebo. Results: There was statistically significant difference (p-value <0.05) between both groups as regard infertility duration (months), ovulation rate, no. of chemical pregnancies and no. of clinical pregnancies. There was highly statistically significant difference (p-value < 0.001) between both groups as regard days until HCG injection, endometrial thickness (mm), no. of pre-ovulatory follicles >17 mm and E2 on day of HCG injection. Conclusion: Adding L-carnitine to clomiphene from the follicular phase and extending through the luteal phase in patients with clomiphene-resistant PCOS, at the given dose and duration, may be of beneficial to the quality of ovulation and the clinical pregnancy rate. | ||
| Keywords | ||
| L-carnitine; clomiphene-resistant; PCOs; Pregnancy | ||
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