Uterine transplantation: a review of current progress, challenges and future directions | ||
| Aswan Africa Obstetrics and Gynecology Journal | ||
| Article 2, Volume 1, Issue 2 - Serial Number 1, June 2025, Pages 10-17 PDF (450.86 K) | ||
| Document Type: Review article | ||
| DOI: 10.21608/aaogj.2025.389787.1015 | ||
| Author | ||
| Hanan Jawad* | ||
| Specialist of Obstetrics & Gynecology. Arbil - Iraq | ||
| Abstract | ||
| Uterine transplantation (UT) is a fertility restoring treatment for women with absolute uterine factor infertility. Uterine transplantation (UT) associated with IVF restores fertility in women affected by absolute uterine factor infertility (AUFI). Pregnancies achieved both in women undergoing any solid organ transplantation and following IVF are associated with an increased risk of maternal and neonatal complications(5) Purpose: To provide a comprehensive review of uterine transplantation including discussion of pregnancy outcomes, donor and recipient selection process, organ procurement and transplant surgeries, reported complications, pre-implant preparation, and ethical considerations.(2) Objective: This review aims to summarize the current state of uterine transplantation, including its indications, surgical techniques (living versus dead donors, robotic versus open surgery), donor choices, immunosuppression protocols, reproductive outcomes, ethical challenges and future prospects.(2) Methods: A comprehensive literature review was conducted from the PubMed, , and Web of Science databases, focusing on clinical trials, case reports, and cohort studies published between 2000 and 2024. Uterine implantation has emerged as a new treatment for absolute uterine factor infertility (AUFI), providing the possibility of pregnancy and childbirth in the absence of other options. a condition that was previously considered irreversible. This condition, which affects about 1 in 500 women globally, includes different scenarios. Results: Since the first successful live birth after UT in 2014,more than 100 operations have been performed worldwide, with increasing live birth rates approaching 50% in experienced centers. However, there are still Key challenges such as graft rejection, immunosuppressive management, surgical complexity, psychosocial considerations, and ethical concerns about donor safety. | ||
| Keywords | ||
| Uterine transplantation; Uterine factor infertility; immunosuppression; Reproductive surgery; Ethical Considerations in Organ Transplantation | ||
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