Investigating the Role of Irisin in Metabolic Health: A Study on Obese Patients with and without Diabetes. | ||||
| Egyptian Journal of Chemistry | ||||
| Articles in Press, Accepted Manuscript, Available Online from 01 June 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2025.336459.10807 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Shimaa Rabie Saber  1; Soha M. Hamdy1; Khaled G. Abdel-Wahhab2
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| 1Department of Chemistry, Faculty of Science, Fayoum University, Fayoum. | ||||
| 2Department of Medical Physiology, National Research Centre, Giza, Egypt. | ||||
| Abstract | ||||
| The objective of this study was to investigate the association between circulating irisin and various anthropometric and biochemical parameters in obese patients. The study comprised 60 participants, categorized into three distinct groups: group I, designated as "control" (N = 20), group II, referred to "obese" (N = 20), and group III, referred to as "obese with diabetic ” (N = 20 It should be clarified that the diagnoses of BMI and weight Inex[H1] are based on the measurements of body mass index and weight. They demonstrated a non-significant variation in the Body Mass Index (BMI) measures and a non-significant diffing of the obese group from the control group, followed by a non-significant increment of the diabetic group. However, alongside these the obese and diabetic categories had significant increases compared to the control group, as well as the obese and diabetic condition had significant increases following the control. The acquired data demonstrated that, when both subjects were compared to the control group, obese subjects had a significant increase in serum Alanine Aminotransferase( ALAT) and Aspartate Aminotransferase (ASAT )activity (6.7%, -19.7%, respectively), whereas obese subjects with diabetes showed variation in serum ALAT and ASAT activity (26.3%, -10%).When compared to the control group, the kidney function parameters for both the obese and the obese with diabetes showed a significant increase (7.1%, -5.3%) for urea and a slight increase (12.5%, 25%) for creatinine. The groups showed variation (3.5%, 5.4%) for Fasting Blood Sugar (FBS) and 2 hour Postprandial Sugar (2PPBS) for the obese groups, but an increase (123.5%, 143.5%) for the obese with diabetes groups. However, there was a notable increase in Hemoglobin A1C (HbA1C) (26.2% vs. 140.5%) as well when compared to control groups in the obese and obese with diabetes groups. Furthermore, oxidative stress marker data showed a significant increase in obese subjects compared to controls (65.9%,-16.7%,-24.3%,-3.5%, -7.0%). However, when these groups were compared to the control, there were highly significant differences for Irisin and Tumor necrosis Factor (TNF-α) (-3.1%, 207.1%) in the obese group and (-18.1%, 407.1%) in the obese with diabetes group. | ||||
| Keywords | ||||
| Keywords: Obese patients; Obese with diabetic patients; Irisin; HBA1C. TNF- α | ||||
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