Fetal Main Pulmonary Artery Doppler and Lamellar Body Count in Amniotic Fluid as Predictors for Respiratory Distress Syndrome Development | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Volume 29, Issue 3 - Serial Number 11106352, May 2025, Pages 36-45 PDF (403.29 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2025.431333 | ||
| Authors | ||
| Heba Farag Mohamed Salama1; Mohamed Abdelghani Emaraa2; Dena Mamdouh Serag3; Kerolos Usama Henry Sorial* 4; Mohamed Sabry Ahmed Rawash5 | ||
| 1Ass. Prof. of Obstetrics and Gynecology, Menoufia University, | ||
| 2Prof. of Obstetrics and Gynecology, Menoufia University | ||
| 3Ass. Prof. of Diagnostic and Interventional Radiology, Medical Imaging, Menoufia University | ||
| 4Ob/Gyn Resident Doctor at EL-Tahrir General Hospital Imbaba | ||
| 5Lecturer of Obstetrics and Gynecology, Menoufia University | ||
| Abstract | ||
| Context: Insufficient surfactant in the underdeveloped fetal lungs can cause severe respiratory distress syndrome (RDS), potentially necessitating specialized management during delivery. Aims: Investigate the lamellar body count in amniotic fluid and fetal main pulmonary artery doppler measures as possible markers for the onset of respiratory distress syndrome. Settings and Design: This cross-sectional study included 118 pregnant women scheduled for elective Cesarean sec-tion. Participants were recruited from Menoufia Univer-sity Hospital and El-Tahrir General Hospital in Imbaba. Methods and Material: All the studied cases were sub-jected to: Detailed personal and obstetric histories in-cluded information such as:(Age, BMI, Sex, Gravidity, Parity, Gestational age, Previous CS, Previous PTL, Cor-ticosteroids and Corticosteroids dose time), Ultrasound Examinations, Cesarean section and delivery assessment, Post-Delivery Neonatal Evaluation. Statistical analysis used: Data analysis was conducted using SPSS version 24, which stands for the Statistical Program for the Social Sciences. Results: Patients with respiratory distress syndrome (RDS) can be reliably identified using the pulmonary ar-tery pulsatility index (PI) when the cut off value is more than 2.55. It shows 81.8% sensitivity, 100% specificity, 100% positive predictive value (PPV), and 98.2% nega-tive predictive value (NPV) with an area under the curve (AUC) of 0.96 and a p-value less than 0.001. Also, with a cutoff value higher than 0.89, the pulmonary artery resis-tance index (RI) can distinguish RDS in these patients. It has a 0.9 area under the curve (AUC) and a p-value of less than 0.001, in addition to 81.8% sensitivity, 85% specific-ity, 36% PPV, and 97.8% NPV. Conclusions: A fetal main pulmonary artery Doppler measurement, an amniotic fluid lamellar body count (LBC) and pulmonary artery index can be used to an-ticipate neonatal respiratory distress syndrome (RDS). In conjunction with lower LBC and higher Pulmonary Artery Pulsatility Index (PI) and Resistance Index (RI), these non-invasive methods of fetal lung maturity evaluation are very helpful in assessing the risk of RDS. | ||
| Keywords | ||
| Fetal Main Pulmonary Artery Doppler; Lamellar Body Count; Respiratory Distress Syndrome | ||
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