Fetal Main Pulmonary Artery Doppler and Lamellar Body Count in Amniotic Fluid as Predictors for Respiratory Distress Syndrome Development
Salama, H., Emaraa, M., Serag, D., Sorial, K., Rawash, M. (2025). Fetal Main Pulmonary Artery Doppler and Lamellar Body Count in Amniotic Fluid as Predictors for Respiratory Distress Syndrome Development. EKB Journal Management System, 29(3), 36-45. doi: 10.21608/egyfs.2025.431333
Heba Farag Mohamed Salama; Mohamed Abdelghani Emaraa; Dena Mamdouh Serag; Kerolos Usama Henry Sorial; Mohamed Sabry Ahmed Rawash. "Fetal Main Pulmonary Artery Doppler and Lamellar Body Count in Amniotic Fluid as Predictors for Respiratory Distress Syndrome Development". EKB Journal Management System, 29, 3, 2025, 36-45. doi: 10.21608/egyfs.2025.431333
Salama, H., Emaraa, M., Serag, D., Sorial, K., Rawash, M. (2025). 'Fetal Main Pulmonary Artery Doppler and Lamellar Body Count in Amniotic Fluid as Predictors for Respiratory Distress Syndrome Development', EKB Journal Management System, 29(3), pp. 36-45. doi: 10.21608/egyfs.2025.431333
Salama, H., Emaraa, M., Serag, D., Sorial, K., Rawash, M. Fetal Main Pulmonary Artery Doppler and Lamellar Body Count in Amniotic Fluid as Predictors for Respiratory Distress Syndrome Development. EKB Journal Management System, 2025; 29(3): 36-45. doi: 10.21608/egyfs.2025.431333

Fetal Main Pulmonary Artery Doppler and Lamellar Body Count in Amniotic Fluid as Predictors for Respiratory Distress Syndrome Development

The Egyptian Journal of Fertility and Sterility
Volume 29, Issue 3 - Serial Number 11106352, May 2025, Page 36-45  XML PDF (403.29 K)
Document Type: Original Article
DOI: 10.21608/egyfs.2025.431333
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Authors
Heba Farag Mohamed Salama1; Mohamed Abdelghani Emaraa2; Dena Mamdouh Serag3; Kerolos Usama Henry Sorial email 4; Mohamed Sabry Ahmed Rawash5
1Ass. Prof. of Obstetrics and Gynecology, Menoufia University,
2Prof. of Obstetrics and Gynecology, Menoufia University
3Ass. Prof. of Diagnostic and Interventional Radiology, Medical Imaging, Menoufia University
4Ob/Gyn Resident Doctor at EL-Tahrir General Hospital Imbaba
5Lecturer of Obstetrics and Gynecology, Menoufia University
Abstract
Context: Insufficient surfactant in the underdeveloped fetal lungs can cause severe respiratory distress syndrome (RDS), potentially necessitating specialized management during delivery.   
Aims: Investigate the lamellar body count in amniotic fluid and fetal main pulmonary artery doppler measures as possible markers for the onset of respiratory distress syndrome.   
Settings and Design: This cross-sectional study included 118 pregnant women scheduled for elective Cesarean sec-tion. Participants were recruited from Menoufia Univer-sity Hospital and El-Tahrir General Hospital in Imbaba. 
Methods and Material: All the studied cases were sub-jected to: Detailed personal and obstetric histories in-cluded information such as:(Age, BMI, Sex, Gravidity, Parity, Gestational age, Previous CS, Previous PTL, Cor-ticosteroids and Corticosteroids dose time), Ultrasound Examinations, Cesarean section and delivery assessment, Post-Delivery Neonatal Evaluation.
Statistical analysis used: Data analysis was conducted using SPSS version 24, which stands for the Statistical Program for the Social Sciences. 
Results: Patients with respiratory distress syndrome (RDS) can be reliably identified using the pulmonary ar-tery pulsatility index (PI) when the cut off value is more than 2.55. It shows 81.8% sensitivity, 100% specificity, 100% positive predictive value (PPV), and 98.2% nega-tive predictive value (NPV) with an area under the curve (AUC) of 0.96 and a p-value less than 0.001. Also, with a cutoff value higher than 0.89, the pulmonary artery resis-tance index (RI) can distinguish RDS in these patients. It has a 0.9 area under the curve (AUC) and a p-value of less than 0.001, in addition to 81.8% sensitivity, 85% specific-ity, 36% PPV, and 97.8% NPV.
Conclusions: A fetal main pulmonary artery Doppler measurement, an amniotic fluid lamellar body count (LBC) and pulmonary artery index can be used to an-ticipate neonatal respiratory distress syndrome (RDS). In conjunction with lower LBC and higher Pulmonary Artery Pulsatility Index (PI) and Resistance Index (RI), these non-invasive methods of fetal lung maturity evaluation are very helpful in assessing the risk of RDS.
Keywords
Fetal Main Pulmonary Artery Doppler; Lamellar Body Count; Respiratory Distress Syndrome
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