Role of Hyaluronic Acid Intrauterine Injection in Asherman’s Syndrome in Women Undergoing Hysteroscopy
El Shalakany, A., Kaldas, N., Samy, M., Ghaleb, M. (2025). Role of Hyaluronic Acid Intrauterine Injection in Asherman’s Syndrome in Women Undergoing Hysteroscopy. EKB Journal Management System, 29(3), 72-82. doi: 10.21608/egyfs.2025.431336
Amr Hassan El Shalakany; Nancy Naiem Kaldas; Mohammed Mahmoud Samy; Mahmoud Mohamed Ghaleb. "Role of Hyaluronic Acid Intrauterine Injection in Asherman’s Syndrome in Women Undergoing Hysteroscopy". EKB Journal Management System, 29, 3, 2025, 72-82. doi: 10.21608/egyfs.2025.431336
El Shalakany, A., Kaldas, N., Samy, M., Ghaleb, M. (2025). 'Role of Hyaluronic Acid Intrauterine Injection in Asherman’s Syndrome in Women Undergoing Hysteroscopy', EKB Journal Management System, 29(3), pp. 72-82. doi: 10.21608/egyfs.2025.431336
El Shalakany, A., Kaldas, N., Samy, M., Ghaleb, M. Role of Hyaluronic Acid Intrauterine Injection in Asherman’s Syndrome in Women Undergoing Hysteroscopy. EKB Journal Management System, 2025; 29(3): 72-82. doi: 10.21608/egyfs.2025.431336

Role of Hyaluronic Acid Intrauterine Injection in Asherman’s Syndrome in Women Undergoing Hysteroscopy

The Egyptian Journal of Fertility and Sterility
Volume 29, Issue 3 - Serial Number 11106352, May 2025, Pages 72-82    PDF (318.15 K)
Document Type: Original Article
DOI: 10.21608/egyfs.2025.431336
Authors
Amr Hassan El Shalakany1; Nancy Naiem Kaldas* 2; Mohammed Mahmoud Samy3; Mahmoud Mohamed Ghaleb3
1Professor of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University
2Master degree, Resident of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University
3Assistant Professor of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University
Abstract
Background: Asherman’s syndrome an acquired disorder resulting from pregnancy, childbirth, infection, uterine in-tervention or repair of abnormalities in the uterus (e.g., intrauterine septum, bicornuate uterus or myomectomy).    
Aim of the Work: Investigating the efficacy of injecting Hyaluronic acid intrauterine in Asherman’s patients using hyster oscopic adhesiolysis.   
Patients and Methods: This randomized clinical trial was conducted at Early Cancer Detection & Endoscopy Unit maternity hospital Ain Shams University from Janu-ary 2023 till March 2024. 
Results: The Cases Group showed an increase from 8.3% before treatment to 41.7% after treatment, while the Con-trol Group remained relatively stable at 33.3% both be-fore and after treatment. Similarly, the proportion of par-ticipants experiencing mild symptoms in the Cases Group increased from 33.3% before treatment to 50.0% after treatment, whereas the Control Group remained consis-tent at 33.3%. However, the reduction in amenorrhea in the case group compared to the control group, but an in-significant difference between the two groups.
Conclusion: Intrauterine adhesions can result from surgi-cal or hysteroscopic intervention, it can be corrected ef-fectively and safely with the use of hysteroscop to restore menstural pattern and fertility. 
Keywords
Hyaluronic Acid Intrauterine Injection; Ash-erman’s Syndrome; Hysteroscopy
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