Vaginal versus sublingual misoprostol administration before intrauterine device insertion in women with previous failed trial
Salama, H., Hosni, N., Salem, O., Ellakwa, H. (2025). Vaginal versus sublingual misoprostol administration before intrauterine device insertion in women with previous failed trial. EKB Journal Management System, 29(3), 109-116. doi: 10.21608/egyfs.2025.431339
Heba Farag Salama; Nehad Mahmoud Hosni; Omnia Hanafy Salem; Hamed El Sayed Ellakwa. "Vaginal versus sublingual misoprostol administration before intrauterine device insertion in women with previous failed trial". EKB Journal Management System, 29, 3, 2025, 109-116. doi: 10.21608/egyfs.2025.431339
Salama, H., Hosni, N., Salem, O., Ellakwa, H. (2025). 'Vaginal versus sublingual misoprostol administration before intrauterine device insertion in women with previous failed trial', EKB Journal Management System, 29(3), pp. 109-116. doi: 10.21608/egyfs.2025.431339
Salama, H., Hosni, N., Salem, O., Ellakwa, H. Vaginal versus sublingual misoprostol administration before intrauterine device insertion in women with previous failed trial. EKB Journal Management System, 2025; 29(3): 109-116. doi: 10.21608/egyfs.2025.431339

Vaginal versus sublingual misoprostol administration before intrauterine device insertion in women with previous failed trial

The Egyptian Journal of Fertility and Sterility
Volume 29, Issue 3 - Serial Number 11106352, May 2025, Page 109-116  XML PDF (349.44 K)
Document Type: Original Article
DOI: 10.21608/egyfs.2025.431339
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Authors
Heba Farag Salama1; Nehad Mahmoud Hosni1; Omnia Hanafy Salem email 2; Hamed El Sayed Ellakwa1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2Family planning clinic at El Hawamdia primary health care, Giza
Abstract
Background: Intrauterine device (IUD) is one of the most efficient contraceptive techniques, despite its low use rate due to the user's fear of discomfort and the pro-vider's insertion issues. Misoprostol is a drug that softens and facilitates dilatation of the cervix.   
Objectives: The aim of the current work was to com-pare the efficacy of using misoprostol (Vaginally versus sublingually) before IUD insertion in cases of previously failed trial.   
Patients and methods: A prospective interventional comparative study included 80 women who had history of failed previous IUD insertion, attending at Outpatient Clinics, Menoufia university and El Hawamdia prima-ry health care, from April 2022 till August 2023 .There were randomly divided into Group A which included 40 women who used misoprostol vaginally, 2-4 hours before IUD insertion and group B included 40 women who used misoprostol sublingually 2-4 hours before IUD insertion. Success of IUD insertion, participant pain and satisfac-tion were compared between the two groups. 
Results: There was statistically significant difference be-tween vaginal misoprostol group and sublingual group regarding IUD insertion with a P value of 0.034. There was also highly significant difference in the occurrence of pain with a P value of 0.001 according to visual analog scale and numeric rating scale.
Conclusion: usage of Vaginal misoprostol (400 µg) 2-4 h before IUD insertion increase the rate of IUD and reduces the incidence of pain during the procedure. 
Keywords
intrauterine device; sublingual misoprostol; vaginal misoprostol; cervical ripening
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