Mean gestational sac diameter, Embryonic heart rate and CA-125 as prognostic factors for first trimesteric outcome | ||||
| Benha Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 02 June 2025 PDF (649.5 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2025.376344.2372 | ||||
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| Authors | ||||
Mohamed A Farag1; Amr A Sharaf El-Dine2; Ali A Bendary2; Mohamed M Ibrahim El-elemi  3
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| 1Department of Obstetrics and gynecology, Faculty of Medicine Benha University | ||||
| 2Department of Obstetrics and gynecology, Faculty of Medicine - Benha University | ||||
| 3(MB.B.Ch Cairo University 2015),Resident of Obstetrics and Gynecology ,El-Mounira Puplic Hospital | ||||
| Abstract | ||||
| Background: Ultrasound parameters such as fetal heart rate, diameter of gestational sac, length of crown rump are the criteria determined to assess early pregnancy. Aim: To evaluate the predictive role of Cancer Antigen 125 (CA-125), fetal heart rate and gestational sac diameters for the outcome of the pregnancy. Patients and methods: This group research has been performed at Benha University Hospitals and El-Monira General Hospital after obtaining approach of their related Ethics committees. This research has been performed on 70 pregnant women at 6-13 weeks of gestation. Results: There was statistically insignificant distinction found among the control group and the patient group regarding the first visit Mean Sac Diameter (MSD), Crown-Rump Length (CRL), and Fetal Heart Rate (FHR), with p-values of 0.710, 0.416, 0.229, and 0.086. However, there was a statistically significant negative assosiation found among (CA125) levels and Fetal Heart Rate (FHR) in the studied patients. Conclusion: CA125 can be used as a good, cheap, available and non-invasive predictor for occurrence of pregnancy loss at a cutoff value > 33 iu\ml with AUC, sensitivity, specificity, PLR, NLR, +PV, -PV of 0.871, 80.0, 84.62, 5.2, 0.24, 54.5, 94.8 respectively. Also first trimester ultrasound parameters can be used as a predictor for occurrence of pregnancy loss which is available, easy to apply, cheap and non-invasive. | ||||
| Keywords | ||||
| Gestational sac; MSD; CRL; FHR; CA125 | ||||
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