Cytokeratin 18 as marker for non-invasive diagnosis of acute liver diseases
Fahmey, S., Abdel-Aziz, M., Gomaa, Y., Hodeib, M. (2025). Cytokeratin 18 as marker for non-invasive diagnosis of acute liver diseases. EKB Journal Management System, 6(2), 142-150. doi: 10.21608/ejmr.2024.270437.1559
Sameh S Fahmey; Manar M Abdel-Aziz; Yara M Gomaa; Mahmoud Hodeib. "Cytokeratin 18 as marker for non-invasive diagnosis of acute liver diseases". EKB Journal Management System, 6, 2, 2025, 142-150. doi: 10.21608/ejmr.2024.270437.1559
Fahmey, S., Abdel-Aziz, M., Gomaa, Y., Hodeib, M. (2025). 'Cytokeratin 18 as marker for non-invasive diagnosis of acute liver diseases', EKB Journal Management System, 6(2), pp. 142-150. doi: 10.21608/ejmr.2024.270437.1559
Fahmey, S., Abdel-Aziz, M., Gomaa, Y., Hodeib, M. Cytokeratin 18 as marker for non-invasive diagnosis of acute liver diseases. EKB Journal Management System, 2025; 6(2): 142-150. doi: 10.21608/ejmr.2024.270437.1559

Cytokeratin 18 as marker for non-invasive diagnosis of acute liver diseases

Egyptian Journal of Medical Research
Volume 6, Issue 2, April 2025, Page 142-150  XML PDF (406.38 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2024.270437.1559
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Authors
Sameh S Fahmey1; Manar M Abdel-Aziz2; Yara M Gomaa email 3; Mahmoud Hodeib1
1Pediatrics department, Faculty of Medicine, Beni-Suef University, Egypt
2Clinical and Chemical Pathology department Faculty of Medicine, Beni- Suef University,Egypt
3Pediatrics department, Matay General hospital, Minia, Egypt.
Abstract
Background: Assessment of CK-18 cell death biomarkers allows for the early detection of liver damage in acute liver diseases. Our aim of work is to prove that CK-18 cell death biomarkers in serum enables early detection of liver damage in acute liver diseases. Patients and methods: a cross sectional study that conducted. It included 40 child with acute liver disease and compared to 25 age and sex matched childen as a control group who presented at outpatient clinics and inpatient departments in Beni-Suef university hospital. All patients underwent complete history taking, complete physical examination and investigations including Alanine Aminotransferase, Aspartate Transaminas, Albumin, CBC, CRP, Urea ,creatinine and Serum CK -18  measurement using ELISA kit. Results: CK18 levels were significantly higher in liver disease patients than controls. There was significantly difference between the studied groups regarding their CK18 level. There was insignificant correlation between CK18 and labs in Acute Hepatitis. There was a significant positive correlation between CK18 and INR in fulminant hepatitis. When ROC curve was plotted, CK18 was found to have a significant role in diagnosing of liver disease as Acute Hepatitis  and Fulminant Hepatitis  with reasonable sensitivity, specificity, PPV, NPV. Conclusion and recommendations: CK18 may help in diagnosis of liver diseases in children. Further multicenter studies on a large number of populations with serial measurements of CK18 levels are recommended to further evaluate the role of CK18 in the diagnosis of liver disease in children and to detect the prognostic value of CK18 regarding mortality.
Keywords
Cytokeratin-18; CK18; liver diseases; Children
References
  1. Jagadisan, B., Srivastava, A., Yachha, S. K., & Poddar, U. (2012). Acute on chronic liver disease in children from the developing world: recognition and prognosis. Journal of pediatric gastroenterology and nutrition, 54(1), 77-82.‏
  2. Hanif, M., Raza, J., Qureshi, H., & Issani, Z. (2004). Etiology of chronic liver disease in children. JOURNAL-PAKISTAN MEDICAL ASSOCIATION, 54(3), 119-122
  3. Mandelia, C., Collyer, E., Mansoor, S., Lopez, R., Lappe, S., Nobili, V., & Alkhouri, N. (2016). Plasma cytokeratin-18 level as a novel biomarker for liver fibrosis in children with nonalcoholic fatty liver disease. Journal of pediatric gastroenterology and nutrition, 63(2), 181-187.‏
  4. Canbay, A., Feldstein, A., Kronenberger, B., Schulze-Osthoff, K., & Bantel, H. (2014). Cytokeratin 18 as marker for non-invasive diagnosis and prognosis of acute and chronic liver diseases. Zeitschrift fur Gastroenterologie, 52(3), 290-295.‏
  5. Mandelia, C., Collyer, E., Mansoor, S., Lopez, R., Lappe, S., Nobili, V., & Alkhouri, N. (2016). Plasma cytokeratin-18 level as a novel biomarker for liver fibrosis in children with nonalcoholic fatty liver disease. Journal of pediatric gastroenterology and nutrition, 63(2), 181-187.‏
  6. Ramadan, H. K. A., Sayed, I. M., Elkhawaga, A. A., Meghezel, E. Z. M., Askar, A. A., Moussa, A. M., et al & El-Mokhtar, M. A. (2023). Characteristics and outcomes of acute hepatitis of unknown etiology in Egypt: First report of adult adenovirus-associated hepatitis. Infection, 51(4), 887-895.‏
  7. Elbeltagi, R., Al-Beltagi, M., Saeed, N. K., Bediwy, A. S., & Toema, O. (2023). May 2022 acute hepatitis outbreak, is there a role for COVID-19 and other viruses?. World Journal of Hepatology, 15(3), 364.‏
  8. Tanwar, G. S. (2022). Clinical and Etiopathological Correlation of Acute Infective Hepatitis and Fulminant Hepatic Failure in Pediatric Patients. Online Journal of Health and Allied Sciences, 21(1).‏
  9. Suttorp, M., & Classen, C. F. (2021). Splenomegaly in children and adolescents. Frontiers in pediatrics, 9, 704635.‏
  10. Yang, Z. H., Yang, S. X., Qin, C. Z., & Chen, Y. X. (2015). Clinical values of elevated serum cytokeratin-18 levels in hepatitis: a meta-analysis. Hepatitis monthly, 15(5).‏
  11. Aida, Y., Abe, H., Tomita, Y., Nagano, T., Seki, N., Sugita, T., et al & Aizawa, Y. (2014). Serum cytokeratin 18 fragment level as a noninvasive biomarker for non-alcoholic fatty liver disease. International journal of clinical and experimental medicine, 7(11), 4191.‏
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