ASSESSMENT OF IN VIVO ANTIEPILEPTIC POTENTIAL OF FRUIT PEEL EXTRACT OF CITRUS MEDICA
Jyothi, D., Dsouza, U., KS, C., Dath, S. (2025). ASSESSMENT OF IN VIVO ANTIEPILEPTIC POTENTIAL OF FRUIT PEEL EXTRACT OF CITRUS MEDICA. EKB Journal Management System, (), -. doi: 10.21608/bfsa.2025.358573.2429
Divya Jyothi; Ullas Prakash Dsouza; Chandrashekhar KS; Sanjana Dath. "ASSESSMENT OF IN VIVO ANTIEPILEPTIC POTENTIAL OF FRUIT PEEL EXTRACT OF CITRUS MEDICA". EKB Journal Management System, , , 2025, -. doi: 10.21608/bfsa.2025.358573.2429
Jyothi, D., Dsouza, U., KS, C., Dath, S. (2025). 'ASSESSMENT OF IN VIVO ANTIEPILEPTIC POTENTIAL OF FRUIT PEEL EXTRACT OF CITRUS MEDICA', EKB Journal Management System, (), pp. -. doi: 10.21608/bfsa.2025.358573.2429
Jyothi, D., Dsouza, U., KS, C., Dath, S. ASSESSMENT OF IN VIVO ANTIEPILEPTIC POTENTIAL OF FRUIT PEEL EXTRACT OF CITRUS MEDICA. EKB Journal Management System, 2025; (): -. doi: 10.21608/bfsa.2025.358573.2429

ASSESSMENT OF IN VIVO ANTIEPILEPTIC POTENTIAL OF FRUIT PEEL EXTRACT OF CITRUS MEDICA

Bulletin of Pharmaceutical Sciences Assiut University
Articles in Press, Accepted Manuscript, Available Online from 03 June 2025  XML
Document Type: Original Article
DOI: 10.21608/bfsa.2025.358573.2429
View on SCiNiTO View on SCiNiTO
Authors
Divya Jyothi email orcid 1; Ullas Prakash Dsouzaorcid 2; Chandrashekhar KS3; Sanjana Dath4
1Department of Pharmacognosy, Pharmacy, Nitte deemed to be University, NGSM Institute of Pharmaceutical Sciences, Mangalore, India
2Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences Institute of Pharmaceutical Sciences, Nitte (Deemed to be) University, Mangalore, India
3Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India
4NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be) University, Deralakatte, Karnataka, India.
Abstract
ABSTRACT

Epilepsy is a neurological disorder and anti-epileptic drugs presently in use are incapable of effectively managing seizures and have various side effects of medications. Thus, there is a need for a new antiepileptic drug with higher efficacy and fewer side effects. In this study Extracts of fruit peel of Citrus medica were subjected to antiepileptic activity against maximal electroshock (MES) and Pentylene tetrazole (PTZ)-induced convulsions animal models and lithium/pilocarpine-induced status epilepticus. Extracts of Citrus medica (100,200 and 400 mg/kg) has significantly reduced the time- period of extensor phase in MES model and extended the onset of clonic convulsions in PTZ model, respectively. In lithium-pilocarpine model, Citrus medica extract exhibited significant decreases in the severity of status epilepsy in proportion to the dose of the extract, when correlated with the control group. Citrus medica extract at 400 mg/kg exhibited significant antiepileptic activity which is comparable with that of standard drug.
Keywords
Citrus; Anticonvulsant; Fruit peel extract
Statistics
Article View: 59