Bioactive Potential of Ajuga iva (L.) Schreb. from Western Algeria: Phenolic Content, Antioxidant, and Antibacterial Activities | ||||
| Egyptian Journal of Botany | ||||
| Articles in Press, Accepted Manuscript, Available Online from 01 July 2025 PDF (1.4 MB) | ||||
| Document Type: Regular issue (Original Article) | ||||
| DOI: 10.21608/ejbo.2025.339856.3096 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ikram SENOUCI  ; Aicha Megherbi Benali; fawzia Toumi
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| Department of environmental sciences, Faculty of natural and life sciences, Uniersity Djilali Liabes, sidi bel abbes, Algeria. | ||||
| Abstract | ||||
| This study investigates the bioactive potential of Ajuga iva collected from Western Algeria, focusing on its phytochemical composition, antioxidant activity, and antibacterial effects. After harvesting, the plant material was dried, ground, and extracted using ethanol, methanol, and water. Phytochemical screening confirmed the presence of major bioactive compounds, including phenolics, flavonoids, and saponins. Quantitative analysis revealed differences in composition among the extracts, each displaying a distinct profile of secondary metabolites. The antioxidant activity was measured using the DPPH radical scavenging assay. Among the tested extracts, the ethanolic one showed the highest antioxidant capacity, with the lowest IC₅₀ value. In addition, the antibacterial properties of the hydroalcoholic extract were assessed using the disc diffusion method against four bacterial strains. The extract showed concentration-dependent inhibition, with Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) being more sensitive, while Gram-negative strains (Escherichia coli and Pseudomonas aeruginosa) demonstrated greater resistance. The results support the potential of Ajuga iva as a valuable source of natural antioxidants and antimicrobial agents. Its rich phenolic content and biological activity validate its traditional uses in folk medicine and suggest further applications in the development of plant-based therapeutic products. Future studies involving essential oils, purified compounds, and pharmacological models are recommended to enhance the understanding of its therapeutic potential and promote its valorization as a natural bioresource. | ||||
| Keywords | ||||
| Ajuga iva; Phenolic compounds; Antioxidant activity; Antibacterial activity; DPPH assa; Algeria | ||||
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