The impact of perinatal fluoxetine exposure on rat pregnant females and their offspring | ||
| Bulletin of Faculty of Science, Zagazig University | ||
| Article 7, Volume 2025, Issue 3, July 2025, Pages 73-81 PDF (1.38 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfszu.2025.340079.1450 | ||
| Authors | ||
| Mostafa A. Salem1; Asmaa A. A. Kattaia2; Radwa A. Anwar* 3; Eman H. El sheikh4 | ||
| 1Zoology department, faculty of science, Zagazig University, Zagazig, Egypt | ||
| 2medical histology and cell biology, Faculty of medicine, Zagazig University, Zagazig, Egypt | ||
| 3Embryology and Comparative anatomy, Zoology Department, faculty of science, Zagazig University, Zagazig, Egypt | ||
| 4zoology department, faculty of science, Zagazig university, Zagazig, Egypt | ||
| Abstract | ||
| Pregnancy and after childbirth are the most critical periods to develop depression illness because of hormonal fluctuations. Fluoxetine (FLX) is one of the most regularly prescribed antidepressants, with 1.9–2.1 percent of pregnant women using FLX at some stage. In the current study, we aimed to study clinical signs of toxicity for both mothers and offspring after exposure to FLX during pregnancy and lactation. For adult female albino rats, we also investigated the hepatotoxicity that FLX injection caused. We found that perinatal FLX exposure increases the mortality rate for both pregnant rats and their offspring. FLX exposure also led to an adverse effect on embryo development as it increased embryo resorption. Additionally, cannibalism behavior in rats exposed to FLX appeared against their offspring. On the other hand, we did not find a significant difference in vaginal bleeding for pregnant rats after exposed to prenatal FLX. Hepatic damage also was discovered by histopathological assessment of the liver in female adult rats following FLX exposure. Our results show perinatal FLX treatment at the dose 25mg/kg/day in the pregnant and postpartum mothers led to clinical signs of toxicity for both dam and offspring. | ||
| Keywords | ||
| Antidepressants; Hepatotoxicity; perinatal Depression; weaning weight | ||
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