Doxorubicin toxicity in bone marrow cells of female mice (Mus musculus) | ||||
| Bulletin of Faculty of Science, Zagazig University | ||||
| Article 12, Volume 2025, Issue 3, July 2025, Page 130-133 PDF (1 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfszu.2025.343094.1455 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
sara ahmed el-said  1; Sabha E. Elballat2; iman el-sayed el-araby3; Fawzeya abdel elhady Zayed4
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| 1zoology.faculty of scince.zagazig univeristy | ||||
| 2Zoology department, faculty of science, Zagazig University, Zagazig, Egypt | ||||
| 3animal wealth development department veterinary medicin | ||||
| 4Zoology Department, Faculty of Science, Zagazig University, | ||||
| Abstract | ||||
| Doxorubicin (Dox), anti-cancer drug, was administered to female mice at a dose of 0.027 mg/ml water once every 7 days for 30 days to determine its toxicity on chromosomes. Adult female mice (Mus musculus) were divided randomly into 3 main groups; control group, control positive group and DOX (chemotherapy group). The results of the present work supported that DOX as anti- tumor dug is cytotoxic and it must be carefully used. Its combination with a strong antioxidant agent is recommended for normal tissue protection.Chromosomal aberrations occur when aspirated bone marrow cells were fixed and stained with Giemsa specific stain, to examine the arrested cell cycle at the metaphase for clearly detect ion and examination of the chromosomal numerical or structural aberration that diagnoses the chromosomal mutations that lead to cancer induction . In the present study it was found that there highly statistically significant difference between total chromosomal aberrations at control and all studied groups. While the chromosomal aberration is classified into numerical and structural. | ||||
| Keywords | ||||
| cancer; Chromosomal aberrations; Doxorubicin | ||||
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