USING OF PROBIOTICS AND PROPIONIC ACID AGAINST E. COLI INFECTION IN BROILER CHICKENS | ||||
| Assiut Veterinary Medical Journal | ||||
| Article 2, Volume 71, Issue 186, July 2025, Page 16-31 PDF (871.91 K) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.2025.366849.1618 | ||||
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| Authors | ||||
GHADA M. EL KHDER1; DOAA I.A. MOSTAFA   2; NOHA ABD EL RAHMAN1; SARA A. ABD ELWAHAB3; SHAIMAA A. ABD EL-KADER4; NANIES S.E. SALIM3; MOHAMED E. DARWISH 5
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| 1Biochemistry, Toxicology and Feed Deficiency Department, Animal Health Research Institute (AHRI), Doki, Agricultural Research Center (ARC), Dokki, Egypt | ||||
| 2Clinical Pathology Department, Animal Health Research Institute (AHRI), Zagazig Branch, Agricultural Research Center (ARC), Zagzig, Egypt | ||||
| 3Biochemistry, Toxicology and Feed Deficiency Department, Animal Health Research Institute (AHRI), Zagazig Branch, Agricultural Research Center (ARC), Zagzig, Egypt | ||||
| 4Microbiology Department, Animal Health Research Institute (AHRI), Zagazig Branch, Agricultural Research Center (ARC), Zagzig, Egypt | ||||
| 53 Feed Deficiency Department, Animal Health Research Institute (AHRI), Zagazig Branch, Agricultural Research Center (ARC), Zagzig, Egypt | ||||
| Abstract | ||||
| A total of 400 swabs (cloacal, oral) were collected from 200 one-day-old chicks for bacteriological examination. One hundred one-day-old chicks were divided into 5 equal groups, Gp (1) healthy chicks (control), Gp (2) infected (positive control), Gp (3 and 4) chicks received ½ kg probiotic/ton ration and 0.1 ml propionic acid/liter drinking water for 30 days from respectively, and Gp (5) treated by 10 mg doxycycline/kg Bwt in drinking water for 5 consecutive days (from 15-20 days old). Gp (2, 3, 4, and 5) broilers infected with E coli at 15th day old. On the 20th and 30th days old. Blood and tissue samples were collected, and re-isolation of E. coli was carried out. Broilers of group (2) showed signs of colibacillosis, reduction in body performance, and antioxidant enzymes, in addition to an increase in WBCs and heterophiles, and impairment in liver and kidney functions at 20 days old. Broilers infected with E. coli and receiving probiotic, propionic acid, or doxycycline treatment showed improvement in clinical signs, body performance, leukogram, liver and kidney function tests, antioxidant enzyme activity, and immunity. However, doxycycline residues were found in the kidney, liver, and breast muscle at the 20th day old and completely disappeared from all examined tissues by the 30th day old. The high residue was detected in the kidney, followed by the liver then the breast muscle. It could be concluded that probiotics, propionic acid and doxycycline control E. coli infection, and improve growth performance, and hematological and biochemical parameters in broilers, so it is good to use probiotic and propionic acid throughout the entire fattening period of broilers as growth promoters and to control E. coli infections. | ||||
| Keywords | ||||
| Performance; E coli; doxycycline; residue; hematobiochemical | ||||
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