Newer antimicrobial strategies to combat biofilm formation and antimicrobial resistance in Acinetobacter baumannii | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 05 June 2025 | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/mid.2025.355894.2487 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sunil Kumar   1; G.R. Neel 2; Mukesh Yadav 3; Nirmala Sehrawat 3; Ashwani Kumar 4; Anil Kumar Sharma 5
| ||||
| 1Department of Microbiology, Graphic Era Deemed to be University, Dehradun, Uttarakhand, India | ||||
| 2Department of Microbiolgy, Kampala International University, Western Campus, Ishaka, Uganda | ||||
| 3Department of Biosciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India | ||||
| 4Department of Biotechnology, Chaudhary Bansi Lal University, Bhiwani, Haryana, India | ||||
| 5Department of Biotechnology, School of Biological Sciences, Amity University Punjab, Mohali-140306, India | ||||
| Abstract | ||||
| Background: In the recent years, a variety of virulence factors have been observed to contribute to biofilm formation by virtue of which bacteria may survive in stressful conditions. The rate of biofilm formation in Acinetobacter baumannii is comparatively more than in other bacterial species. As per the data from previous investigations, 59.6–91.0% of A. baumannii isolates displayed the ability to form biofilm on various sites. A. baumannii is an opportunistic pathogen, which causes an array of hospital-acquired infections (HAIs) like; ventilator-associated pneumonia (VAP), septicemia, urinary tract, meningitis, and wound infections especially in intensive care units (ICUs). As per the World Health Organization (WHO) guidelines, A. baumannii which is one of the significant pathogens of ESKAPE group, displayed strong resistance against multiple antimicrobials. A. baumannii exhibits multidrug resistance (MDR) through various forms including; biofilm formation, overexpression of efflux pumps, increased enzyme production, horizontal gene transfer, decreased permeability, altered targets, and other metabolic changes. Ability of A. baumannii to synthesize biofilm is a key factor for the development of multidrug resistance. Gene expression is also reportedly altered by biofilm formation, which is responsible for elevated adaptive antibiotic resistance. Medical devices are more prone to be colonized by A. baumannii biofilm when used for prolonged period of time. Biofilms are serious impediment for treating infections due to their intrinsic resistance to a range of antimicrobials. In this review, we describe novel approaches and future interventions to control biofilm formation and to alleviate the antimicrobial resistance in A. baumannii. | ||||
| Keywords | ||||
| Acinetobacter baumannii; Antimicrobial Resistance; Biofilm; Infections | ||||
|
Statistics Article View: 111 |
||||
