Assessing antimicrobial resistance of Escherichia coli: A One Health Perspective | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 05 June 2025 | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/mid.2025.357710.2507 | ||||
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| Authors | ||||
Rajeshwari Lekhwar 1; Sunil Kumar  1; Anju Rani 1; Saurabh Gangola 1; Rachan Karmakar 2; G.R. Neel 3
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| 1Department of Microbiology, Graphic Era (Deemed to be University), Bell Road, Clement Town, Dehradun, Uttarakhand, India | ||||
| 2Department of Environmental Sciences, Graphic Era (Deemed to be University), Bell Road, Clement Town, Dehradun, Uttarakhand, India | ||||
| 3Department of Microbiology, Kampala International University, Western Campus, Ishaka, Uganda | ||||
| Abstract | ||||
| Background: Antimicrobial resistance (AMR) is a major public health concern that is posing a serious threat to the global healthcare system along with One Health consortium. One Health concept is the collaboration of multiple professions to address environmental, animal, and human health issues. The goal of the integrated, unifying One Health approach is to optimize and sustainably balance the health of people, animals, and ecosystems. Antimicrobial resistance is said to occur when bacteria mutate and these genes are formed when the bacteria change their path towards specific drugs that have been formulated to cure infections caused by the pathogenic microbes. AMR is also said to occur naturally (intrinsically) and acquired resistance (mutations) due to excessive and inappropriate use of antimicrobial drugs in various situations. As per CDC report, E. coli has been reported in numerous sources, such as the environment, food, water, and both human and animal intestines and also as a causative agent of gastrointestinal infections in animals and people. Many samples like; meat from poultry, soil and litter samples from agricultural land have shown resistance genes in the recovered isolates of E. coli. Due to their relevance to the topicality of AMR, especially in E. coli, many studies included in this review aimed to address public health issues. This review also discussed the extended-spectrum beta-lactamases (ESBL) produced by E. coli associated with antimicrobial resistance while depicting a One Health model that integrates the environment, animals and humans. | ||||
| Keywords | ||||
| Antimicrobial resistance; Extended-Spectrum Beta-Lactamase; Multi-Drug Resistance; One Health | ||||
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