Phytochemical-Assisted Green Synthesis of Antioxidant and Antimicrobial Silver Nanoparticles Using Cichorium Intybus Extract for Enhanced Medical Cotton Fabrics
Ghiniwa, A., Zahran, M., El Rafie, H., Ayad, E., Abdelaziz, M., Mohamed, T. (2025). Phytochemical-Assisted Green Synthesis of Antioxidant and Antimicrobial Silver Nanoparticles Using Cichorium Intybus Extract for Enhanced Medical Cotton Fabrics. EKB Journal Management System, 68(9), 715-728. doi: 10.21608/ejchem.2025.369657.11482
Aya Ibrahim Ghiniwa; Magdy K. Zahran; Hanaa El Rafie; Eman Ayad; Mohamed Abdelaziz; Tamer Samy Mohamed. "Phytochemical-Assisted Green Synthesis of Antioxidant and Antimicrobial Silver Nanoparticles Using Cichorium Intybus Extract for Enhanced Medical Cotton Fabrics". EKB Journal Management System, 68, 9, 2025, 715-728. doi: 10.21608/ejchem.2025.369657.11482
Ghiniwa, A., Zahran, M., El Rafie, H., Ayad, E., Abdelaziz, M., Mohamed, T. (2025). 'Phytochemical-Assisted Green Synthesis of Antioxidant and Antimicrobial Silver Nanoparticles Using Cichorium Intybus Extract for Enhanced Medical Cotton Fabrics', EKB Journal Management System, 68(9), pp. 715-728. doi: 10.21608/ejchem.2025.369657.11482
Ghiniwa, A., Zahran, M., El Rafie, H., Ayad, E., Abdelaziz, M., Mohamed, T. Phytochemical-Assisted Green Synthesis of Antioxidant and Antimicrobial Silver Nanoparticles Using Cichorium Intybus Extract for Enhanced Medical Cotton Fabrics. EKB Journal Management System, 2025; 68(9): 715-728. doi: 10.21608/ejchem.2025.369657.11482

Phytochemical-Assisted Green Synthesis of Antioxidant and Antimicrobial Silver Nanoparticles Using Cichorium Intybus Extract for Enhanced Medical Cotton Fabrics

Egyptian Journal of Chemistry
Volume 68, Issue 9, September 2025, Page 715-728  XML PDF (1.01 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2025.369657.11482
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Authors
Aya Ibrahim Ghiniwa1; Magdy K. Zahran2; Hanaa El Rafieorcid 3; Eman Ayad4; Mohamed Abdelazizorcid 5; Tamer Samy Mohamed email orcid 6
1Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
2Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo, 11795, Egypt.
3National Research Center
4Helwan University
5National research Center
6Laboratory of Medicinal Chemistry, Theodor Bilharz Institute, Korniash El-Nile, 12411 Warrak El-Hadar, Giza, Egypt.
Abstract
This study evaluates antimicrobial cotton fabrics functionalized with silver nanoparticles (AgNPs) biosynthesized using Cichorium intybus L. (chicory) leaf extract. The eco-friendly synthesis leveraged phytoconstituents as dual reducing and stabilizing agents. Characterization via UV-vis spectroscopy (λmax=400 nm) and TEM confirmed spherical AgNPs (4.5–10.9 nm), while SEM-EDX verified uniform coating on cotton. The AgNP-cotton demonstrated enhanced antimicrobial efficacy against Gram-positive Staphylococcus aureus (25 mm inhibition zone), Gram-negative Escherichia coli (23 mm), fungal Candida albicans (25 mm), and Aspergillus niger (21 mm), attributed to AgNP-induced membrane disruption and ROS generation. Phytochemical analysis identified flavonoids, phenolics, and alkaloids with high concentrations (128.17 mg RE/g flavonoids; 459.94 mg GAE/g phenolics). Antioxidant assays revealed strong radical scavenging (IC50: 9.21 µg/mL ABTS; 17.14 µg/mL DPPH). This sustainable integration of phytochemicals and nanotechnology presents eco-friendly antimicrobial textiles with potential for medical applications, such as wound dressings and hospital linens, offering alternatives to conventional treatments.
Keywords
Cichorium intybus; UPLC-QTOF MS; Silver nanoparticles; Green synthesis; Antimicrobial textiles; Antioxidant activity
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