Efficacy of Truffle on Serum Lipids and Antioxidant Status in Male Rats | ||||
| Egyptian Journal of Nutrition | ||||
| Articles in Press, Accepted Manuscript, Available Online from 09 June 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/enj.2025.389868.1117 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Heba Ibrahim Mahmoud11; Mohammed Hamdy Haggag1; Osama El-Sayed Mostafa22 | ||||
| 11- Nutrition and Food Sciences Department., Faculty of Home Economics, Helwan University, Cairo Egypt | ||||
| 22- Home economics Fa culty of Specific Education, Ain Shams University, Cairo, Egypt. | ||||
| Abstract | ||||
| ABSTRACT This research was conducted in order to examine the efficacy of truffle on eliminating oxidative stress of male rats. Thirty-six male rats were divided into six groups (6 rats of each) as follow; The 1st group was fed on basal diet as a negative control, the 2nd group was as the same of group 1 and was intraperitoneally injected with potassium dichromate at a dose 10mg/kg BW as a positive control, the 3rd, 4th and 5th as the same of group 2 with 300, 400 and 500 mg hydroethanolic truffle dried extract/Kg BW. Whereas, the 6th group as the same of group 2 with 500 mg truffle powder /Kg BW, respectively. At the end of experiment (after 8 weeks), rats were fasted over night before scarifying. Serum kidney and liver functions as well as lipid profile, oxidative and anti-oxidative markers were analysed. Kidney and liver were removed from each rat to histopathological examination. The results indicated that truffle extract or its powder caused significant decreased (P˂0.05) in serum TC, TG, LDL-c, VLDL-c and MDA but significant increase in HDL-c and CAT compared to the +ve control group. Otherwise, histopathological examination showed improvement in kidney and liver of groups treated with truffle extract(showed improvement on kidney and liver of groups treated with truffle extract( as concentration 500mg group 5) or its powder(as concentration 500mg group 6) compared with +ve control group. According to these above results, the usage of truffle extract or its powder as natural agent may be effective in reducing the risk of oxidative stress so may play a therapeutic role of human beings. | ||||
| Keywords | ||||
| Key words: Oxidative stress; Truffle; Antioxidant; HDL; CAT; potassium dichromate | ||||
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