A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells
Abdel-Rahman, A., Zaki, M., Zaid, I., Salama, W., Hawata, M., Zaki, Y., Gomha, S., Farag, B., Abdelgawad, F., Amer, H. (2025). A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells. EKB Journal Management System, 68(13), 789-802. doi: 10.21608/ejchem.2025.367652.11440
Adel A -H Abdel-Rahman; Magdi E. A. Zaki; Ibrahim F. Zaid; Wafaa M. Salama; Mohamed A. Hawata; Yasser H. Zaki; Sobhi M. Gomha; Basant Farag; Fathy E. Abdelgawad; Hamada H. Amer. "A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells". EKB Journal Management System, 68, 13, 2025, 789-802. doi: 10.21608/ejchem.2025.367652.11440
Abdel-Rahman, A., Zaki, M., Zaid, I., Salama, W., Hawata, M., Zaki, Y., Gomha, S., Farag, B., Abdelgawad, F., Amer, H. (2025). 'A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells', EKB Journal Management System, 68(13), pp. 789-802. doi: 10.21608/ejchem.2025.367652.11440
Abdel-Rahman, A., Zaki, M., Zaid, I., Salama, W., Hawata, M., Zaki, Y., Gomha, S., Farag, B., Abdelgawad, F., Amer, H. A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells. EKB Journal Management System, 2025; 68(13): 789-802. doi: 10.21608/ejchem.2025.367652.11440

A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells

Egyptian Journal of Chemistry
Volume 68, Issue 13, December 2025, Pages 789-802    PDF (1.58 M)
Document Type: Original Article
DOI: 10.21608/ejchem.2025.367652.11440
Authors
Adel A -H Abdel-Rahman1; Magdi E. A. Zaki2; Ibrahim F. Zaid1; Wafaa M. Salama1; Mohamed A. Hawata1; Yasser H. Zaki* 3; Sobhi M. Gomha4; Basant Farag5; Fathy E. Abdelgawad4; Hamada H. Amer6, 7
1Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt.
2Department of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia;
3Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt.
4Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia
5Department of Chemistry, Faculty of Science, Zagazig University, 44519 Egypt.
6Animal Medicine and Infectious Diseases Department, Faculty of Veterinary Medicine, University of Sadat City, Egypt.
7Chemistry Department, University College of Turabah, Taif University, Turabah, Taif, Saudi Arabia.
Abstract
A novel series of benzimidazolo-[1,2,4]triazole-tetrazole derivatives was synthesized and evaluated for anticancer potential through integrated in silico and in vitro approaches. Molecular docking against the 8GVZ anticancer target revealed that compounds 4, 5, 7, 9, and 11 exhibited superior binding affinities, surpassing the reference drug 5-fluorouracil. ADMET predictions confirmed favorable pharmacokinetic and toxicity profiles, supporting their drug-likeness. Subsequent in vitro assays against MCF-7 breast cancer cells demonstrated potent cytotoxicity, with compound 11 showing the lowest IC₅₀ value (0.21 μM). These findings highlight compound 11 and its analogs as promising leads for further anticancer drug development.
Keywords
Benzimidazoles; Triazoles; Tetrazoles; Anticancer; Computational Modeling; ADMET Prediction
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