A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells
Zaki, Y., Abdel-Rahman, A., Gomha, S., Amer, H., Salama, W., Hawata, M., farag, B., Zaid, I., Zaki, M., Abdelgawad, F. (2025). A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells. EKB Journal Management System, (), -. doi: 10.21608/ejchem.2025.367652.11440
Yasser Hassan Zaki; Adel Abdel-Rahman; sobhi Gomha; Hamada Amer; Wafaa M. Salama; Mohamed Abdallah Hawata; basant farag; Ibrahim F. Zaid; Magdi Zaki; Fathy Abdelgawad. "A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells". EKB Journal Management System, , , 2025, -. doi: 10.21608/ejchem.2025.367652.11440
Zaki, Y., Abdel-Rahman, A., Gomha, S., Amer, H., Salama, W., Hawata, M., farag, B., Zaid, I., Zaki, M., Abdelgawad, F. (2025). 'A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells', EKB Journal Management System, (), pp. -. doi: 10.21608/ejchem.2025.367652.11440
Zaki, Y., Abdel-Rahman, A., Gomha, S., Amer, H., Salama, W., Hawata, M., farag, B., Zaid, I., Zaki, M., Abdelgawad, F. A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells. EKB Journal Management System, 2025; (): -. doi: 10.21608/ejchem.2025.367652.11440

A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells

Egyptian Journal of Chemistry
Articles in Press, Accepted Manuscript, Available Online from 10 June 2025  XML
Document Type: Original Article
DOI: 10.21608/ejchem.2025.367652.11440
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Authors
Yasser Hassan Zaki email orcid 1; Adel Abdel-Rahman2; sobhi Gomha3; Hamada Amer4; Wafaa M. Salama5; Mohamed Abdallah Hawata6; basant farag7; Ibrahim F. Zaid5; Magdi Zaki8; Fathy Abdelgawad3
1Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.
2Chemistry Department, Faculty of Science, Menoufia Univesrity
3Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia
4Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Egypt.
5Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt
6Faculty of science menoufia university shebien ElKoom Egypt
7Department of Chemistry, Faculty of Science, Zagazig University, 44519 Egypt.
8Professor of Organic Chemistry Chemistry Department Science College Al-Imam Mohamed Bin Saud University
Abstract
A novel series of benzimidazolo-[1,2,4]triazole-tetrazole derivatives was synthesized and evaluated for anticancer potential through integrated in silico and in vitro approaches. Molecular docking against the 8GVZ anticancer target revealed that compounds 4, 5, 7, 9, and 11 exhibited superior binding affinities, surpassing the reference drug 5-fluorouracil. ADMET predictions confirmed favorable pharmacokinetic and toxicity profiles, supporting their drug-likeness. Subsequent in vitro assays against MCF-7 breast cancer cells demonstrated potent cytotoxicity, with compound 11 showing the lowest IC₅₀ value (0.21 μM). These findings highlight compound 11 and its analogs as promising leads for further anticancer drug development.
Keywords
Benzimidazoles; Triazoles; Tetrazoles; Anticancer; Computational Modeling; ADMET Prediction
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