A Novel Series of Benzimidazole-Triazole-Tetrazole Compounds: Synthesis, Structural Analysis, and Cytotoxic Activity Against MCF-7 Cells | ||
Egyptian Journal of Chemistry | ||
Volume 68, Issue 13, December 2025, Pages 789-802 PDF (1.56 M) | ||
Document Type: Original Article | ||
DOI: 10.21608/ejchem.2025.367652.11440 | ||
Authors | ||
Adel Abdel-Rahman1; Magdi Zaki2; Ibrahim F. Zaid3; Wafaa M. Salama3; Mohamed Abdallah Hawata4; Yasser Hassan Zaki* 5; sobhi Gomha6; basant farag7; Fathy Abdelgawad6; Hamada Amer8 | ||
1Chemistry Department, Faculty of Science, Menoufia Univesrity | ||
2Professor of Organic Chemistry Chemistry Department Science College Al-Imam Mohamed Bin Saud University | ||
3Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt | ||
4Faculty of science menoufia university shebien ElKoom Egypt | ||
5Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt. | ||
6Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia | ||
7Department of Chemistry, Faculty of Science, Zagazig University, 44519 Egypt. | ||
8Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Egypt. | ||
Abstract | ||
A novel series of benzimidazolo-[1,2,4]triazole-tetrazole derivatives was synthesized and evaluated for anticancer potential through integrated in silico and in vitro approaches. Molecular docking against the 8GVZ anticancer target revealed that compounds 4, 5, 7, 9, and 11 exhibited superior binding affinities, surpassing the reference drug 5-fluorouracil. ADMET predictions confirmed favorable pharmacokinetic and toxicity profiles, supporting their drug-likeness. Subsequent in vitro assays against MCF-7 breast cancer cells demonstrated potent cytotoxicity, with compound 11 showing the lowest IC₅₀ value (0.21 μM). These findings highlight compound 11 and its analogs as promising leads for further anticancer drug development. | ||
Keywords | ||
Benzimidazoles; Triazoles; Tetrazoles; Anticancer; Computational Modeling; ADMET Prediction | ||
Statistics Article View: 315 PDF Download: 12 |